Clinical implications of recent findings in schistosome proteomics

Patrick Driguez, Donald P McManus, Geoffrey N Gobert

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Schistosomiasis is a neglected tropical disease of clinical significance that, despite years of research, still requires an effective vaccine and improved diagnostics for surveillance, control and potential elimination. Furthermore, the causes of host pathology during schistosomiasis are still not completely understood. The recent sequencing of the genomes of the three key schistosome species has enabled the discovery of many new possible vaccine and drug targets, as well as diagnostic biomarkers, using high-throughput and sensitive proteomics methods. This review focuses on the literature of the last 5 years that has reported on the use of proteomics to both better understand the biology of the schistosome parasites and the disease they cause in definitive mammalian hosts.

Original languageEnglish
Pages (from-to)19-33
Number of pages15
JournalExpert review of proteomics
Volume13
Issue number1
Early online date26 Nov 2015
DOIs
Publication statusPublished - 2016

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