Clinical management and outcome of refractory asthma in the UK from the British Thoracic Society Difficult Asthma Registry

Joan Sweeney; Chris E Brightling; Andrew Menzies-Gow; Robert Niven; Chris C Patterson; Liam G Heaney

doi:10.1136/thoraxjnl-2012-201869

Clinical management and outcome of refractory asthma in the UK from the British Thoracic Society Difficult Asthma Registry

Joan Sweeney, Chris E Brightling, Andrew Menzies-Gow, Robert Niven, Chris C Patterson, Liam G Heaney

Research output: Contribution to journal › Article › peer-review

67 Citations (Scopus)

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Abstract

Refractory asthma represents a significant unmet clinical need. Data from a national online registry audited clinical outcome in 349 adults with refractory asthma from four UK specialist centres in the British Thoracic Society Difficult Asthma Network. At follow-up, lung function improved, with a reduction in important healthcare outcomes, specifically hospital admission, unscheduled healthcare visits and rescue courses of oral steroids. The most frequent therapeutic intervention was maintenance oral corticosteroids and most steroid sparing agents (apart from omalizumab) demonstrated minimal steroid sparing benefit. A significant unmet clinical need remains in this group, specifically a requirement for therapies which reduce systemic steroid exposure.

Original language	English
Pages (from-to)	754-756
Number of pages	3
Journal	Thorax
Volume	67
Issue number	8
Early online date	11 May 2012
DOIs	https://doi.org/10.1136/thoraxjnl-2012-201869
Publication status	Published - Aug 2012

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1136/thoraxjnl-2012-201869

Clinical management and outcome of refractory asthma in the UK from the British Thoracic Society Asthma Network
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.
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Improvements in clinical assessment and management of Difficult-to-treat Asthma in Adults
Liam Heaney (Participant), Michael Stevenson (Participant), Diarmuid McNicholl (Participant), Lorcan McGarvey (Participant), Joan Sweeney (Participant) & Christopher Patterson (Participant)
Impact: Health Impact, Quality of Life Impact

Cite this

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abstract = "Refractory asthma represents a significant unmet clinical need. Data from a national online registry audited clinical outcome in 349 adults with refractory asthma from four UK specialist centres in the British Thoracic Society Difficult Asthma Network. At follow-up, lung function improved, with a reduction in important healthcare outcomes, specifically hospital admission, unscheduled healthcare visits and rescue courses of oral steroids. The most frequent therapeutic intervention was maintenance oral corticosteroids and most steroid sparing agents (apart from omalizumab) demonstrated minimal steroid sparing benefit. A significant unmet clinical need remains in this group, specifically a requirement for therapies which reduce systemic steroid exposure.",

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Clinical management and outcome of refractory asthma in the UK from the British Thoracic Society Difficult Asthma Registry

Abstract

ASJC Scopus subject areas

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Improvements in clinical assessment and management of Difficult-to-treat Asthma in Adults

Cite this