Clinical management and outcome of refractory asthma in the UK from the British Thoracic Society Difficult Asthma Registry

Joan Sweeney, Chris E Brightling, Andrew Menzies-Gow, Robert Niven, Chris C Patterson, Liam G Heaney

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)
276 Downloads (Pure)

Abstract

Refractory asthma represents a significant unmet clinical need. Data from a national online registry audited clinical outcome in 349 adults with refractory asthma from four UK specialist centres in the British Thoracic Society Difficult Asthma Network. At follow-up, lung function improved, with a reduction in important healthcare outcomes, specifically hospital admission, unscheduled healthcare visits and rescue courses of oral steroids. The most frequent therapeutic intervention was maintenance oral corticosteroids and most steroid sparing agents (apart from omalizumab) demonstrated minimal steroid sparing benefit. A significant unmet clinical need remains in this group, specifically a requirement for therapies which reduce systemic steroid exposure.
Original languageEnglish
Pages (from-to)754-756
Number of pages3
JournalThorax
Volume67
Issue number8
Early online date11 May 2012
DOIs
Publication statusPublished - Aug 2012

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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