Abstract
Refractory asthma represents a significant unmet clinical need. Data from a national online registry audited clinical outcome in 349 adults with refractory asthma from four UK specialist centres in the British Thoracic Society Difficult Asthma Network. At follow-up, lung function improved, with a reduction in important healthcare outcomes, specifically hospital admission, unscheduled healthcare visits and rescue courses of oral steroids. The most frequent therapeutic intervention was maintenance oral corticosteroids and most steroid sparing agents (apart from omalizumab) demonstrated minimal steroid sparing benefit. A significant unmet clinical need remains in this group, specifically a requirement for therapies which reduce systemic steroid exposure.
Original language | English |
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Pages (from-to) | 754-756 |
Number of pages | 3 |
Journal | Thorax |
Volume | 67 |
Issue number | 8 |
Early online date | 11 May 2012 |
DOIs | |
Publication status | Published - Aug 2012 |
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
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Dive into the research topics of 'Clinical management and outcome of refractory asthma in the UK from the British Thoracic Society Difficult Asthma Registry'. Together they form a unique fingerprint.Impacts
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Improvements in clinical assessment and management of Difficult-to-treat Asthma in Adults
Liam Heaney (Participant), Michael Stevenson (Participant), Diarmuid McNicholl (Participant), Lorcan McGarvey (Participant), Joan Sweeney (Participant) & Christopher Patterson (Participant)
Impact: Health Impact, Quality of Life Impact