Clonal characteirization of sporadic cribriform-morular variant of papillary thyroid carcinoma by laser microdissection based APC mutation analysis

M.M. Subramaniam, T.C. Putti, D. Anuar, P.Y. Chong, N. Shah, Manuel Salto-Tellez, R. Soong

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15 Citations (Scopus)

Abstract

Cribriform-morular variant (C-MV) of papillary thyroid carcinoma (PTC) is a rare and unusual neoplasm composed of multiple histologic components, including cribriform, papillary, solid, tall columnar, and morular patterns. Analyses of gross C-MV of PTC lesions has linked adenomatous polyposis coli (APC) mutations to its pathogenesis; however, the extent of involvement of mutations in the development Of individual components is unclear We report on bidirectional sequencing of the mutation cluster region (codons 1032-1565) of the APC gene in individually laser-microdissected components of a previously unreported C-MV of PTC. A silent Thr1493Thr gene variant was found in all tumoral components, whereas a 5-base-pair frameshift deletion at codon 1309 was identified only in the morules. Neither variant was observed in matched normal thyroid tissue. These results show the histologic components of C-MV of PTC to have some common mutational background, although additional somatic mutations may be involved in the development of morular structures.
Original languageEnglish
Pages (from-to)994-1001
Number of pages8
JournalAmerican Journal of Clinical Pathology
Volume128
Issue number6
DOIs
Publication statusPublished - Dec 2007

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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