Cloning and characterization of the mouse homologue of the human dendritic cell maturation marker CD208/DC-LAMP

B. Salaun, B. De Saint-Vis, V. Clair-Moninot, J.J. Pin, C. Barthelemy-Dubois, Adrien Kissenpfennig, C. Peronne, E. Bates, M.G. Mattei, S. Lebecque

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)
13 Downloads (Pure)


DC-LAMP, a member of the lysosomal-associated membrane protein (LAMP) family, is specifically expressed by human dendritic cells (DC) upon activation and therefore serves as marker of human DC maturation. DC-LAMP is detected first in activated human DC within MHC class II molecules-containing compartments just before the translocation of MHC class II-peptide complexes to the cell surface, suggesting a possible involvement in this process. The present study describes the cloning and characterization of mouse DC-LAMP, whose predicted protein sequence is over 50% identical to the human counterpart. The mouse DC-LAMP gene spans over 25 kb and shares syntenic chromosomal localization (16B2-B4 and 3q26) and conserved organization with the human DC-LAMP gene. Analysis of mouse DC-LAMP mRNA and protein revealed the expression in lung peripheral cells, but also its unexpected absence from mouse lymphoid organs and from mouse DC activated either in vitro or in vivo. In conclusion, mouse DC-LAMP is not a marker of mature mouse DC and this observation raises new questions regarding the role of human DC-LAMP in human DC.
Original languageEnglish
Pages (from-to)2619-2629
Number of pages11
JournalEuropean Journal of Immunology
Issue number9
Publication statusPublished - 01 Sep 2003

ASJC Scopus subject areas

  • Immunology


Dive into the research topics of 'Cloning and characterization of the mouse homologue of the human dendritic cell maturation marker CD208/DC-LAMP'. Together they form a unique fingerprint.

Cite this