CNS Remyelination and the Innate Immune System

Christopher E McMurran, Clare A Jones, Denise C Fitzgerald, Robin J M Franklin

Research output: Contribution to journalReview articlepeer-review

33 Citations (Scopus)
175 Downloads (Pure)

Abstract

A misguided inflammatory response is frequently implicated in myelin damage. Particularly prominent among myelin diseases, multiple sclerosis (MS) is an autoimmune condition, with immune-mediated damage central to its etiology. Nevertheless, a robust inflammatory response is also essential for the efficient regeneration of myelin sheaths after such injury. Here, we discuss the functions of inflammation that promote remyelination, and how these have been experimentally disentangled from the pathological facets of the immune response. We focus on the contributions that resident microglia and monocyte-derived macrophages make to remyelination and compare the roles of these two populations of innate immune cells. Finally, the current literature is framed in the context of developing therapies that manipulate the innate immune response to promote remyelination in clinical myelin disease.

Original languageEnglish
Pages (from-to)38
JournalFrontiers in Cell and Developmental Biology
Volume4
DOIs
Publication statusPublished - 03 May 2016
Externally publishedYes

Keywords

  • Journal Article
  • Review

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