Coadministration of L‐alanine and L‐glutamine ameliorate blood glucose levels, biochemical indices and histological features in alloxan‐induced diabetic rats

Ifeanyi J. Ezeonwumelu, Abduljalil M. Mode, Umar F. Magaji, Nnamdi A. Nzoniwu, Muhamad H. Tangaza, Fatima I. Tanimu, Shamsudeen U. Dandare*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated the effects of supplementation of L-alanine and L-glutamine on blood glucose levels and biochemical parameters in alloxan-induced diabetic rat. Forty-nine animals were distributed into seven equal groups. Except for the non-diabetic control, diabetes was induced in all groups by intravenous alloxan injection followed by daily supplementation with amino acids for 14 days. Weight and blood glucose were monitored during supplementation, while biochemical parameters such as liver and renal functions, lipid profile, and antioxidant markers were evaluated post-intervention. A significant increase (p < .05) in weight and decrease in blood glucose were observed in the amino acid(s) treated groups. The supplementation with both amino acids restored important tissue antioxidants, liver and kidney functions and rescued islets cells degeneration. Histopathological examinations of important tissues showed the restoration of alloxan-induced physiopathological changes by the amino acids. Thus, these amino acids might serve as nutraceuticals for the management and treatment of diabetes.


Original languageEnglish
Article numbere14420
JournalJournal of Food Biochemistry
Volume46
Issue number12
Early online date20 Sept 2022
DOIs
Publication statusPublished - 01 Dec 2022

Keywords

  • Cell Biology
  • Pharmacology
  • Food Science
  • Biophysics

Fingerprint

Dive into the research topics of 'Coadministration of L‐alanine and L‐glutamine ameliorate blood glucose levels, biochemical indices and histological features in alloxan‐induced diabetic rats'. Together they form a unique fingerprint.

Cite this