Cofilin immunolabelling correlates with depth of invasion in gastrointestinal endocrine cell tumors

B. Yan, C.T. Yap, S. Wang, C.K. Lee, S. Koh, M.F. Omar, Manuel Salto-Tellez, M.P. Kumarasinghe

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Gastrointestinal endocrine cell tumors are a heterogeneous population of lesions believed to arise from neuroendocrine cells of the gastrointestinal mucosa. The current classification of these tumors is based on tumor size, microscopic features and clinical evidence of metastasis. Although diagnostic categories generally correlate with prognosis, molecular prognostic markers will be clinically useful adjuncts. Cofilin has been implicated in tumor invasion, and its immunolocalisation was studied in gastrointestinal endocrine cell tumors. The immunolocalisation of cofilin was studied by immunohistochemistry in 34 formalin-fixed, paraffin wax-embedded gastrointestinal endocrine cell tumors using a tissue microarray platform. A significant correlation was found between high cofilin immunolabelling and the depth of invasion (p
Original languageEnglish
Pages (from-to)101-106
Number of pages6
JournalActa Histochemica
Volume112
Issue number1
DOIs
Publication statusPublished - Jan 2010

ASJC Scopus subject areas

  • Cell Biology
  • Histology

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