Cognitive functioning in subjects with recent-onset psychosis from a low-middle-income environment: Multiple-domain deficits and longitudinal evaluation

Adriana de Mello Ayres, Marcia Scazufca, Paulo Rossi Menezes, Eduardo Yoshio Nakano, Ana Carolina B. Regina, Maristela S. Schaufelberger, Robin M. Murray, Philip K. McGuire, Teresa Rushe, Geraldo F. Busatto

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Cognitive deficits are a key feature of recent-onset psychosis, but there is no consensus on whether such deficits are generalized or confined to specific domains. Besides, it is unclear whether cognitive deficits: a) are found in psychotic patients in samples from outside high-income countries; and b) whether they progress uniformly over time in schizophrenia and affective psychoses. We applied 12 tests organized into eight cognitive domains, comparing psychosis patients (n = 56, time from initial contact = 677.95+/-183.27 days) versus healthy controls (n = 70) recruited from the same area of Sao Paulo, Brazil. Longitudinal comparisons (digit span and verbal fluency) were conducted between a previous assessment of the subjects carried out at their psychosis onset, and the current follow-up evaluation. Psychosis patients differed significantly from controls on five domains, most prominently on verbal memory. Cognitive deficits remained detectable in separate comparisons of the schizophrenia subgroup and, to a lesser extent, the affective psychosis subjects against controls. Longitudinal comparisons indicated significant improvement in schizophrenia, affective psychoses, and control subjects, with no significant group-by-time interactions. Our results reinforce the view that there are generalized cognitive deficits in association with recent-onset psychoses, particularly of non-affective nature, which persist over time. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)157-164
Number of pages8
JournalPsychiatry Research
Volume179
Issue number2
DOIs
Publication statusPublished - 30 Sep 2010

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Activities

  • 1 Visiting an external academic institution

University of São Paulo

Teresa Rushe (Visiting researcher)

2011 → …

Activity: Visiting an external institution typesVisiting an external academic institution

Cite this

Ayres, A. D. M., Scazufca, M., Menezes, P. R., Nakano, E. Y., Regina, A. C. B., Schaufelberger, M. S., Murray, R. M., McGuire, P. K., Rushe, T., & Busatto, G. F. (2010). Cognitive functioning in subjects with recent-onset psychosis from a low-middle-income environment: Multiple-domain deficits and longitudinal evaluation. Psychiatry Research, 179(2), 157-164. https://doi.org/10.1016/j.psychres.2009.11.001