Cohort profile: Design and methods in the eye and vision consortium of UK Biobank

UK Biobank Eye and Vision Consortium

Research output: Contribution to journalReview article

4 Citations (Scopus)
38 Downloads (Pure)

Abstract

Purpose To describe the rationale, methods and research potential of eye and vision measures available in UK Biobank. Participants UK Biobank is a large, multisite, prospective cohort study. Extensive lifestyle and health questionnaires, a range of physical measures and collection of biological specimens are collected. The scope of UK Biobank was extended midway through data collection to include assessments of other measures of health, including eyes and vision. The eye assessment at baseline included questionnaires detailing past ophthalmic and family history, measurement of visual acuity, refractive error and keratometry, intraocular pressure (IOP), corneal biomechanics, spectral domain optical coherence tomography (OCT) of the macula and a disc-macula fundus photograph. Since recruitment, UK Biobank has collected accelerometer data and begun multimodal imaging data (including brain, heart and abdominal MRI) in 100 000 participants. Dense genotypic data and a panel of 20 biochemistry measures are available, and linkage to medical health records for the full cohort has begun. Findings to date A total of 502 665 people aged between 40 and 69 were recruited to participate in UK Biobank. Of these, 117 175 took part in baseline assessment of vision, IOP, refraction and keratometry. A subgroup of 67 321 underwent OCT and retinal photography. The introduction of eye and vision measures in UK Biobank was accompanied by intensive training, support and a data monitoring quality control process. Future plans UK Biobank is one of the largest prospective cohorts worldwide with extensive data on ophthalmic diseases and conditions. Data collection is an ongoing process and a repeat of the baseline assessment including the questionnaires, measurements and sample collection will be performed in subsets of 25 000 participants every 2-3 years. The depth and breadth of this dataset, coupled with its open-access policy, will create a powerful resource for all researchers to investigate the eye diseases in later life.

Original languageEnglish
Article numbere025077
JournalBMJ Open
Volume9
Issue number2
DOIs
Publication statusPublished - 01 Feb 2019

Fingerprint

Eye Diseases
Optical Coherence Tomography
Intraocular Pressure
Health
Multimodal Imaging
Specimen Handling
Training Support
Refractive Errors
Photography
Biomechanical Phenomena
Quality Control
Biochemistry
Visual Acuity
Medical Records
Life Style
Cohort Studies
Research Personnel
Prospective Studies
Brain
Research

Keywords

  • dementia
  • epidemiology
  • medical ophthalmology
  • medical retina

Cite this

UK Biobank Eye and Vision Consortium. / Cohort profile : Design and methods in the eye and vision consortium of UK Biobank. In: BMJ Open. 2019 ; Vol. 9, No. 2.
@article{f42ee010ab914f199504353279d1dff3,
title = "Cohort profile: Design and methods in the eye and vision consortium of UK Biobank",
abstract = "Purpose To describe the rationale, methods and research potential of eye and vision measures available in UK Biobank. Participants UK Biobank is a large, multisite, prospective cohort study. Extensive lifestyle and health questionnaires, a range of physical measures and collection of biological specimens are collected. The scope of UK Biobank was extended midway through data collection to include assessments of other measures of health, including eyes and vision. The eye assessment at baseline included questionnaires detailing past ophthalmic and family history, measurement of visual acuity, refractive error and keratometry, intraocular pressure (IOP), corneal biomechanics, spectral domain optical coherence tomography (OCT) of the macula and a disc-macula fundus photograph. Since recruitment, UK Biobank has collected accelerometer data and begun multimodal imaging data (including brain, heart and abdominal MRI) in 100 000 participants. Dense genotypic data and a panel of 20 biochemistry measures are available, and linkage to medical health records for the full cohort has begun. Findings to date A total of 502 665 people aged between 40 and 69 were recruited to participate in UK Biobank. Of these, 117 175 took part in baseline assessment of vision, IOP, refraction and keratometry. A subgroup of 67 321 underwent OCT and retinal photography. The introduction of eye and vision measures in UK Biobank was accompanied by intensive training, support and a data monitoring quality control process. Future plans UK Biobank is one of the largest prospective cohorts worldwide with extensive data on ophthalmic diseases and conditions. Data collection is an ongoing process and a repeat of the baseline assessment including the questionnaires, measurements and sample collection will be performed in subsets of 25 000 participants every 2-3 years. The depth and breadth of this dataset, coupled with its open-access policy, will create a powerful resource for all researchers to investigate the eye diseases in later life.",
keywords = "dementia, epidemiology, medical ophthalmology, medical retina",
author = "{UK Biobank Eye and Vision Consortium} and Chua, {Sharon Yu Lin} and Dhanes Thomas and Naomi Allen and Andrew Lotery and Parul Desai and Praveen Patel and Zaynah Muthy and Cathie Sudlow and Tunde Peto and Khaw, {Peng Tee} and Foster, {Paul J.} and Yalin Zheng and Tariq Aslam and Barman, {Sarah A.} and Barrett, {Jenny H.} and Paul Bishop and Peter Blows and Catey Bunce and Carare, {Roxana O.} and Usha Chakravarthy and Michelle Chan and Crabb, {David P.} and Cumberland, {Philippa M.} and Alexander Day and Bal Dhillon and Dick, {Andrew D.} and Cathy Egan and Sarah Ennis and Marcus Fruttiger and Gallacher, {John E.J.} and Garway-Heath, {David F.} and Jane Gibson and Dan Gore and Guggenheim, {Jeremy A.} and Hammond, {Chris J.} and Alison Hardcastle and Harding, {Simon P.} and Hogg, {Ruth E.} and Pirro Hysi and Keane, {Pearse A.} and Khawaja, {Anthony P.} and Gerassimos Lascaratos and Tom MacGillivray and Sarah Mackie and Keith Martin and Michelle McGaughey and Bernadette McGuinness and McKay, {Gareth J.} and Euan Paterson and Woodside, {Jayne V.}",
year = "2019",
month = "2",
day = "1",
doi = "10.1136/bmjopen-2018-025077",
language = "English",
volume = "9",
journal = "BMJ Open",
issn = "2044-6055",
publisher = "BMJ Publishing Group",
number = "2",

}

Cohort profile : Design and methods in the eye and vision consortium of UK Biobank. / UK Biobank Eye and Vision Consortium.

In: BMJ Open, Vol. 9, No. 2, e025077, 01.02.2019.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Cohort profile

T2 - Design and methods in the eye and vision consortium of UK Biobank

AU - UK Biobank Eye and Vision Consortium

AU - Chua, Sharon Yu Lin

AU - Thomas, Dhanes

AU - Allen, Naomi

AU - Lotery, Andrew

AU - Desai, Parul

AU - Patel, Praveen

AU - Muthy, Zaynah

AU - Sudlow, Cathie

AU - Peto, Tunde

AU - Khaw, Peng Tee

AU - Foster, Paul J.

AU - Zheng, Yalin

AU - Aslam, Tariq

AU - Barman, Sarah A.

AU - Barrett, Jenny H.

AU - Bishop, Paul

AU - Blows, Peter

AU - Bunce, Catey

AU - Carare, Roxana O.

AU - Chakravarthy, Usha

AU - Chan, Michelle

AU - Crabb, David P.

AU - Cumberland, Philippa M.

AU - Day, Alexander

AU - Dhillon, Bal

AU - Dick, Andrew D.

AU - Egan, Cathy

AU - Ennis, Sarah

AU - Fruttiger, Marcus

AU - Gallacher, John E.J.

AU - Garway-Heath, David F.

AU - Gibson, Jane

AU - Gore, Dan

AU - Guggenheim, Jeremy A.

AU - Hammond, Chris J.

AU - Hardcastle, Alison

AU - Harding, Simon P.

AU - Hogg, Ruth E.

AU - Hysi, Pirro

AU - Keane, Pearse A.

AU - Khawaja, Anthony P.

AU - Lascaratos, Gerassimos

AU - MacGillivray, Tom

AU - Mackie, Sarah

AU - Martin, Keith

AU - McGaughey, Michelle

AU - McGuinness, Bernadette

AU - McKay, Gareth J.

AU - Paterson, Euan

AU - Woodside, Jayne V.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Purpose To describe the rationale, methods and research potential of eye and vision measures available in UK Biobank. Participants UK Biobank is a large, multisite, prospective cohort study. Extensive lifestyle and health questionnaires, a range of physical measures and collection of biological specimens are collected. The scope of UK Biobank was extended midway through data collection to include assessments of other measures of health, including eyes and vision. The eye assessment at baseline included questionnaires detailing past ophthalmic and family history, measurement of visual acuity, refractive error and keratometry, intraocular pressure (IOP), corneal biomechanics, spectral domain optical coherence tomography (OCT) of the macula and a disc-macula fundus photograph. Since recruitment, UK Biobank has collected accelerometer data and begun multimodal imaging data (including brain, heart and abdominal MRI) in 100 000 participants. Dense genotypic data and a panel of 20 biochemistry measures are available, and linkage to medical health records for the full cohort has begun. Findings to date A total of 502 665 people aged between 40 and 69 were recruited to participate in UK Biobank. Of these, 117 175 took part in baseline assessment of vision, IOP, refraction and keratometry. A subgroup of 67 321 underwent OCT and retinal photography. The introduction of eye and vision measures in UK Biobank was accompanied by intensive training, support and a data monitoring quality control process. Future plans UK Biobank is one of the largest prospective cohorts worldwide with extensive data on ophthalmic diseases and conditions. Data collection is an ongoing process and a repeat of the baseline assessment including the questionnaires, measurements and sample collection will be performed in subsets of 25 000 participants every 2-3 years. The depth and breadth of this dataset, coupled with its open-access policy, will create a powerful resource for all researchers to investigate the eye diseases in later life.

AB - Purpose To describe the rationale, methods and research potential of eye and vision measures available in UK Biobank. Participants UK Biobank is a large, multisite, prospective cohort study. Extensive lifestyle and health questionnaires, a range of physical measures and collection of biological specimens are collected. The scope of UK Biobank was extended midway through data collection to include assessments of other measures of health, including eyes and vision. The eye assessment at baseline included questionnaires detailing past ophthalmic and family history, measurement of visual acuity, refractive error and keratometry, intraocular pressure (IOP), corneal biomechanics, spectral domain optical coherence tomography (OCT) of the macula and a disc-macula fundus photograph. Since recruitment, UK Biobank has collected accelerometer data and begun multimodal imaging data (including brain, heart and abdominal MRI) in 100 000 participants. Dense genotypic data and a panel of 20 biochemistry measures are available, and linkage to medical health records for the full cohort has begun. Findings to date A total of 502 665 people aged between 40 and 69 were recruited to participate in UK Biobank. Of these, 117 175 took part in baseline assessment of vision, IOP, refraction and keratometry. A subgroup of 67 321 underwent OCT and retinal photography. The introduction of eye and vision measures in UK Biobank was accompanied by intensive training, support and a data monitoring quality control process. Future plans UK Biobank is one of the largest prospective cohorts worldwide with extensive data on ophthalmic diseases and conditions. Data collection is an ongoing process and a repeat of the baseline assessment including the questionnaires, measurements and sample collection will be performed in subsets of 25 000 participants every 2-3 years. The depth and breadth of this dataset, coupled with its open-access policy, will create a powerful resource for all researchers to investigate the eye diseases in later life.

KW - dementia

KW - epidemiology

KW - medical ophthalmology

KW - medical retina

U2 - 10.1136/bmjopen-2018-025077

DO - 10.1136/bmjopen-2018-025077

M3 - Review article

C2 - 30796124

AN - SCOPUS:85062003686

VL - 9

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 2

M1 - e025077

ER -