Cohort profile: longitudinal population-based study of COVID-19 in UK adults (COVIDENCE UK)

Hayley Holt, Clare Relton, Mohammad Talaei, Jane Symons, Molly R. Davies, David A. Jolliffe, Giulia Vivaldi, Florence Tydeman, Anne E Williamson, Paul E Pfeffer, Christopher Orton, David V. Ford, Gwyneth A. Davies, Ronan A. Lyons, Christopher J. Griffiths, Frank Kee, Aziz Sheikh, Gerome Breen, Seif O. Shaheen, Adrian R. Martineau

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


The COVIDENCE UK cohort was established to investigate risk factors for, and impacts of, COVID-19 in UK residents aged ≥16 years. A unique feature is the capacity to support trial-within-cohort studies to evaluate interventions for prevention of COVID-19 and other acute respiratory illnesses.

The study was launched on 1 May 2020 and closed to recruitment on 6 October 2021. A total of 19 981 participants enrolled, consented to 5-year follow-up with medical record linkage and completed a detailed online baseline questionnaire capturing self-reported information relating to their sociodemographic characteristics, occupation, lifestyle, quality of life, weight, height, long-standing medical conditions, medication use, vaccination status, diet and supplemental micronutrient intake.

At enrolment, participants’ mean age was 59.1 years (range 16.0 to 94.4 years), 70.2% were female and 93.7% identified their ethnic origin as White.

Follow-up online questionnaires capturing incident symptoms of COVID-19 and other acute respiratory infections, incident swab test-confirmed COVID-19, doses of SARS-CoV-2 vaccine received and quality of life are completed at monthly intervals.

A total of 18 388 (92.0%) participants remained in follow-up on 21 April 2022.

Cohort data are managed by BREATHE—the Health Data Research Hub for Respiratory Health, which is hosted within the Secure Anonymised Information Linkage (SAIL) Databank at Swansea University. Data requests should be addressed to the corresponding author.
Original languageEnglish
Pages (from-to)e46–e56
JournalInternational Journal of Epidemiology
Issue number1
Early online date29 Sept 2022
Publication statusPublished - 01 Feb 2023


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