Cold atmospheric plasma is a viable solution for treating orthopedic infection: A review

Ly Nguyen, Peng Lu, Daniela Boehm, Paula Bourke, Brendan F. Gilmore, Noreen J. Hickok, Theresa A. Freeman*

*Corresponding author for this work

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Bacterial infection and antibiotic resistance are major threats to human health and very few solutions are available to combat this eventuality. A growing number of studies indicate that cold (non-thermal) plasma treatment can be used to prevent or eliminate infection from bacteria, bacterial biofilms, fungi and viruses. Mechanistically, a cold plasma discharge is composed of highenergy electrons that generate short-lived reactive oxygen and nitrogen species which further react to form more stable compounds (NO2, H2O2, NH2Cl and others) depending on the gas mixture and plasma parameters. Cold plasma devices are being developed for medical applications including infection, cancer, plastic surgery applications and more. Thus, in this review we explore the potential utility of cold plasma as a non-antibiotic approach for treating post-surgical orthopedic infections.

Original languageEnglish
Pages (from-to)77-86
JournalBiological Chemistry
Volume400
Issue number1
DOIs
Publication statusPublished - 19 Dec 2018

Fingerprint

Plasma Gases
Orthopedics
Plasmas
Infection
Bacterial Infections
Plasma devices
Reactive Nitrogen Species
Biofilms
Bacterial Drug Resistance
Medical applications
Fungi
Viruses
Gas mixtures
Surgery
Reactive Oxygen Species
Bacteria
Plastic Surgery
Health
Anti-Bacterial Agents
Electrons

Keywords

  • Bacteria
  • Biofilm
  • Cold plasma
  • Orthopedic infection
  • Staphylococcus aureus
  • Titanium

Cite this

Nguyen, Ly ; Lu, Peng ; Boehm, Daniela ; Bourke, Paula ; Gilmore, Brendan F. ; Hickok, Noreen J. ; Freeman, Theresa A. / Cold atmospheric plasma is a viable solution for treating orthopedic infection: A review. In: Biological Chemistry. 2018 ; Vol. 400, No. 1. pp. 77-86.
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abstract = "Bacterial infection and antibiotic resistance are major threats to human health and very few solutions are available to combat this eventuality. A growing number of studies indicate that cold (non-thermal) plasma treatment can be used to prevent or eliminate infection from bacteria, bacterial biofilms, fungi and viruses. Mechanistically, a cold plasma discharge is composed of highenergy electrons that generate short-lived reactive oxygen and nitrogen species which further react to form more stable compounds (NO2, H2O2, NH2Cl and others) depending on the gas mixture and plasma parameters. Cold plasma devices are being developed for medical applications including infection, cancer, plastic surgery applications and more. Thus, in this review we explore the potential utility of cold plasma as a non-antibiotic approach for treating post-surgical orthopedic infections.",
keywords = "Bacteria, Biofilm, Cold plasma, Orthopedic infection, Staphylococcus aureus, Titanium",
author = "Ly Nguyen and Peng Lu and Daniela Boehm and Paula Bourke and Gilmore, {Brendan F.} and Hickok, {Noreen J.} and Freeman, {Theresa A.}",
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Cold atmospheric plasma is a viable solution for treating orthopedic infection: A review. / Nguyen, Ly; Lu, Peng; Boehm, Daniela; Bourke, Paula; Gilmore, Brendan F.; Hickok, Noreen J.; Freeman, Theresa A.

In: Biological Chemistry, Vol. 400, No. 1, 19.12.2018, p. 77-86.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Cold atmospheric plasma is a viable solution for treating orthopedic infection: A review

AU - Nguyen, Ly

AU - Lu, Peng

AU - Boehm, Daniela

AU - Bourke, Paula

AU - Gilmore, Brendan F.

AU - Hickok, Noreen J.

AU - Freeman, Theresa A.

PY - 2018/12/19

Y1 - 2018/12/19

N2 - Bacterial infection and antibiotic resistance are major threats to human health and very few solutions are available to combat this eventuality. A growing number of studies indicate that cold (non-thermal) plasma treatment can be used to prevent or eliminate infection from bacteria, bacterial biofilms, fungi and viruses. Mechanistically, a cold plasma discharge is composed of highenergy electrons that generate short-lived reactive oxygen and nitrogen species which further react to form more stable compounds (NO2, H2O2, NH2Cl and others) depending on the gas mixture and plasma parameters. Cold plasma devices are being developed for medical applications including infection, cancer, plastic surgery applications and more. Thus, in this review we explore the potential utility of cold plasma as a non-antibiotic approach for treating post-surgical orthopedic infections.

AB - Bacterial infection and antibiotic resistance are major threats to human health and very few solutions are available to combat this eventuality. A growing number of studies indicate that cold (non-thermal) plasma treatment can be used to prevent or eliminate infection from bacteria, bacterial biofilms, fungi and viruses. Mechanistically, a cold plasma discharge is composed of highenergy electrons that generate short-lived reactive oxygen and nitrogen species which further react to form more stable compounds (NO2, H2O2, NH2Cl and others) depending on the gas mixture and plasma parameters. Cold plasma devices are being developed for medical applications including infection, cancer, plastic surgery applications and more. Thus, in this review we explore the potential utility of cold plasma as a non-antibiotic approach for treating post-surgical orthopedic infections.

KW - Bacteria

KW - Biofilm

KW - Cold plasma

KW - Orthopedic infection

KW - Staphylococcus aureus

KW - Titanium

U2 - 10.1515/hsz-2018-0235

DO - 10.1515/hsz-2018-0235

M3 - Review article

AN - SCOPUS:85053128952

VL - 400

SP - 77

EP - 86

JO - Biological Chemistry

JF - Biological Chemistry

SN - 1431-6730

IS - 1

ER -