Cold atmospheric pressure plasma jet interactions with plasmid DNA

D. O'Connell; L. J. Cox; W. B. Hyland; S. J. McMahon; S. Reuter; W. G. Graham; T. Gans; F. J. Currell

doi:10.1063/1.3521502

Cold atmospheric pressure plasma jet interactions with plasmid DNA

D. O'Connell, L. J. Cox, W. B. Hyland, S. J. McMahon, S. Reuter, W. G. Graham, T. Gans, F. J. Currell

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Abstract

The effect of a cold (<40 °C) radio frequency-driven atmospheric pressure plasma jet on plasmid DNA has been investigated. Gel electrophoresis was used to analyze the DNA forms post-treatment. The experimental data are fitted to a rate equation model that allows for quantitative determination of the rates of single and double strand break formation. The formation of double strand breaks correlates well with the atomic oxygen density. Taken with other measurements, this indicates that neutral components in the jet are effective in inducing double strand breaks.

Original language	English
Article number	043701
Number of pages	3
Journal	Applied Physics Letters
Volume	98
Issue number	4
DOIs	https://doi.org/10.1063/1.3521502
Publication status	Published - 24 Jan 2011

Bibliographical note

The authors would like to acknowledge support from UK EPSRC through a Career Acceleration Fellowship (EP/H003797/1) and a Science and Innovation Award (EP/D06337X/1), and the Department of Employment and Learning, Northern Ireland.

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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10.1063/1.3521502

Cold atmospheric pressure plasma jet interactions with plasmid DNA
Copyright 2011 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.
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R1050PLI: Interactions between micro-plasma devices
O'Connell, D. (PI)
01/08/2009 → …
Project: Research

Cite this

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abstract = "The effect of a cold (<40 °C) radio frequency-driven atmospheric pressure plasma jet on plasmid DNA has been investigated. Gel electrophoresis was used to analyze the DNA forms post-treatment. The experimental data are fitted to a rate equation model that allows for quantitative determination of the rates of single and double strand break formation. The formation of double strand breaks correlates well with the atomic oxygen density. Taken with other measurements, this indicates that neutral components in the jet are effective in inducing double strand breaks.",

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AU - Graham, W. G.

AU - Gans, T.

AU - Currell, F. J.

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Cold atmospheric pressure plasma jet interactions with plasmid DNA

Abstract

Bibliographical note

ASJC Scopus subject areas

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R1050PLI: Interactions between micro-plasma devices

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