Collagenolytic Activities of the Major Secreted Cathepsin L Peptidases Involved in the Virulence of the Helminth Pathogen, Fasciola hepatica

Mark W Robinson, Ileana Corvo, Peter M Jones, Anthony M George, Matthew P Padula, Joyce To, Martin Cancela, Gabriel Rinaldi, Jose F Tort, Leda Roche, John P Dalton

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

The temporal expression and secretion of distinct members of a family of virulence-associated cathepsin L cysteine peptidases (FhCL) correlates with the entry and migration of the helminth pathogen Fasciola hepatica in the host. Thus, infective larvae traversing the gut wall secrete cathepsin L3 (FhCL3), liver migrating juvenile parasites secrete both FhCL1 and FhCL2 while the mature bile duct parasites, which are obligate blood feeders, secrete predominantly FhCL1 but also FhCL2.
Original languageEnglish
Article numbere1012
Pages (from-to)e1012
JournalPLoS Neglected Tropical Diseases
Volume5
Issue number4
DOIs
Publication statusPublished - Apr 2011

ASJC Scopus subject areas

  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • Pharmacology, Toxicology and Pharmaceutics(all)

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