Collagenolytic Activities of the Major Secreted Cathepsin L Peptidases Involved in the Virulence of the Helminth Pathogen, Fasciola hepatica

Mark W Robinson; Ileana Corvo; Peter M Jones; Anthony M George; Matthew P Padula; Joyce To; Martin Cancela; Gabriel Rinaldi; Jose F Tort; Leda Roche; John P Dalton

doi:10.1371/journal.pntd.0001012

Collagenolytic Activities of the Major Secreted Cathepsin L Peptidases Involved in the Virulence of the Helminth Pathogen, Fasciola hepatica

Mark W Robinson, Ileana Corvo, Peter M Jones, Anthony M George, Matthew P Padula, Joyce To, Martin Cancela, Gabriel Rinaldi, Jose F Tort, Leda Roche, John P Dalton

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

The temporal expression and secretion of distinct members of a family of virulence-associated cathepsin L cysteine peptidases (FhCL) correlates with the entry and migration of the helminth pathogen Fasciola hepatica in the host. Thus, infective larvae traversing the gut wall secrete cathepsin L3 (FhCL3), liver migrating juvenile parasites secrete both FhCL1 and FhCL2 while the mature bile duct parasites, which are obligate blood feeders, secrete predominantly FhCL1 but also FhCL2.

Original language	English
Article number	e1012
Pages (from-to)	e1012
Journal	PLoS Neglected Tropical Diseases
Volume	5
Issue number	4
DOIs	https://doi.org/10.1371/journal.pntd.0001012
Publication status	Published - Apr 2011

ASJC Scopus subject areas

Infectious Diseases
Public Health, Environmental and Occupational Health
Pharmacology, Toxicology and Pharmaceutics(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pntd.0001012

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Robinson, M. W., Corvo, I., Jones, P. M., George, A. M., Padula, M. P., To, J., Cancela, M., Rinaldi, G., Tort, J. F., Roche, L., & Dalton, J. P. (2011). Collagenolytic Activities of the Major Secreted Cathepsin L Peptidases Involved in the Virulence of the Helminth Pathogen, Fasciola hepatica. PLoS Neglected Tropical Diseases, 5(4), e1012. Article e1012. https://doi.org/10.1371/journal.pntd.0001012

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abstract = "The temporal expression and secretion of distinct members of a family of virulence-associated cathepsin L cysteine peptidases (FhCL) correlates with the entry and migration of the helminth pathogen Fasciola hepatica in the host. Thus, infective larvae traversing the gut wall secrete cathepsin L3 (FhCL3), liver migrating juvenile parasites secrete both FhCL1 and FhCL2 while the mature bile duct parasites, which are obligate blood feeders, secrete predominantly FhCL1 but also FhCL2.",

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Robinson, MW, Corvo, I, Jones, PM, George, AM, Padula, MP, To, J, Cancela, M, Rinaldi, G, Tort, JF, Roche, L & Dalton, JP 2011, 'Collagenolytic Activities of the Major Secreted Cathepsin L Peptidases Involved in the Virulence of the Helminth Pathogen, Fasciola hepatica', PLoS Neglected Tropical Diseases, vol. 5, no. 4, e1012, pp. e1012. https://doi.org/10.1371/journal.pntd.0001012

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AU - Robinson, Mark W

AU - Corvo, Ileana

AU - Jones, Peter M

AU - George, Anthony M

AU - Padula, Matthew P

AU - To, Joyce

AU - Cancela, Martin

AU - Rinaldi, Gabriel

AU - Tort, Jose F

AU - Roche, Leda

AU - Dalton, John P

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AB - The temporal expression and secretion of distinct members of a family of virulence-associated cathepsin L cysteine peptidases (FhCL) correlates with the entry and migration of the helminth pathogen Fasciola hepatica in the host. Thus, infective larvae traversing the gut wall secrete cathepsin L3 (FhCL3), liver migrating juvenile parasites secrete both FhCL1 and FhCL2 while the mature bile duct parasites, which are obligate blood feeders, secrete predominantly FhCL1 but also FhCL2.

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DO - 10.1371/journal.pntd.0001012

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ER -

Collagenolytic Activities of the Major Secreted Cathepsin L Peptidases Involved in the Virulence of the Helminth Pathogen, Fasciola hepatica

Abstract

ASJC Scopus subject areas

UN SDGs

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