Common pathways in dementia and diabetic retinopathy: understanding the mechanisms of diabetes-related cognitive decline

Karis Little; María Llorián-Salvador; Sarah Scullion; Cristina Hernández; Olga Simó-Servat; Angel Del Marco; Esmeralda Bosma; Maria Vargas-Soria; Maria Jose Carranza-Naval; Silvia Galbiati; Ilaria Viganò; Clara Alice Musi; Reiner Schlingemann; Jean Feyen; Tiziana Borsello; Gianpaolo Zerbini; Ingeborg Klaassen; Monica Garcia-Alloza; Rafael Simó; Alan W Stitt

doi:10.1016/j.tem.2021.10.008

Common pathways in dementia and diabetic retinopathy: understanding the mechanisms of diabetes-related cognitive decline

Karis Little
, María Llorián-Salvador
, Sarah Scullion
, Cristina Hernández
, Olga Simó-Servat
, Angel Del Marco
, Esmeralda Bosma
, Maria Vargas-Soria
, Maria Jose Carranza-Naval
, Silvia Galbiati
, Ilaria Viganò
, Clara Alice Musi
, Reiner Schlingemann
, Jean Feyen
, Tiziana Borsello
, Gianpaolo Zerbini
, Ingeborg Klaassen
, Monica Garcia-Alloza
, Rafael Simó
, Alan W Stitt

Wellcome Wolfson Institute for Experimental Medicine

Research output: Contribution to journal › Article › peer-review

106 Citations (Scopus)

Abstract

Type 2 diabetes (T2D) is associated with multiple comorbidities, including diabetic retinopathy (DR) and cognitive decline, and T2D patients have a significantly higher risk of developing Alzheimer's disease (AD). Both DR and AD are characterized by a number of pathological mechanisms that coalesce around the neurovascular unit, including neuroinflammation and degeneration, vascular degeneration, and glial activation. Chronic hyperglycemia and insulin resistance also play a significant role, leading to activation of pathological mechanisms such as increased oxidative stress and the accumulation of advanced glycation end-products (AGEs). Understanding these common pathways and the degree to which they occur simultaneously in the brain and retina during diabetes will provide avenues to identify T2D patients at risk of cognitive decline.

Original language	English
Pages (from-to)	50-71
Journal	Trends in Endocrinology & Metabolism
Volume	33
Issue number	1
Early online date	15 Dec 2021
DOIs	https://doi.org/10.1016/j.tem.2021.10.008
Publication status	Published - Jan 2022

Bibliographical note

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Cite this

Little, K., Llorián-Salvador, M., Scullion, S., Hernández, C., Simó-Servat, O., Del Marco, A., Bosma, E., Vargas-Soria, M., Carranza-Naval, M. J., Galbiati, S., Viganò, I., Musi, C. A., Schlingemann, R., Feyen, J., Borsello, T., Zerbini, G., Klaassen, I., Garcia-Alloza, M., Simó, R., & Stitt, A. W. (2022). Common pathways in dementia and diabetic retinopathy: understanding the mechanisms of diabetes-related cognitive decline. Trends in Endocrinology & Metabolism, 33(1), 50-71. https://doi.org/10.1016/j.tem.2021.10.008

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title = "Common pathways in dementia and diabetic retinopathy: understanding the mechanisms of diabetes-related cognitive decline",

abstract = "Type 2 diabetes (T2D) is associated with multiple comorbidities, including diabetic retinopathy (DR) and cognitive decline, and T2D patients have a significantly higher risk of developing Alzheimer's disease (AD). Both DR and AD are characterized by a number of pathological mechanisms that coalesce around the neurovascular unit, including neuroinflammation and degeneration, vascular degeneration, and glial activation. Chronic hyperglycemia and insulin resistance also play a significant role, leading to activation of pathological mechanisms such as increased oxidative stress and the accumulation of advanced glycation end-products (AGEs). Understanding these common pathways and the degree to which they occur simultaneously in the brain and retina during diabetes will provide avenues to identify T2D patients at risk of cognitive decline.",

author = "Karis Little and Mar{\'i}a Llori{\'a}n-Salvador and Sarah Scullion and Cristina Hern{\'a}ndez and Olga Sim{\'o}-Servat and \{Del Marco\}, Angel and Esmeralda Bosma and Maria Vargas-Soria and Carranza-Naval, \{Maria Jose\} and Silvia Galbiati and Ilaria Vigan{\`o} and Musi, \{Clara Alice\} and Reiner Schlingemann and Jean Feyen and Tiziana Borsello and Gianpaolo Zerbini and Ingeborg Klaassen and Monica Garcia-Alloza and Rafael Sim{\'o} and Stitt, \{Alan W\}",

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doi = "10.1016/j.tem.2021.10.008",

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Little, K, Llorián-Salvador, M, Scullion, S, Hernández, C, Simó-Servat, O, Del Marco, A, Bosma, E, Vargas-Soria, M, Carranza-Naval, MJ, Galbiati, S, Viganò, I, Musi, CA, Schlingemann, R, Feyen, J, Borsello, T, Zerbini, G, Klaassen, I, Garcia-Alloza, M, Simó, R & Stitt, AW 2022, 'Common pathways in dementia and diabetic retinopathy: understanding the mechanisms of diabetes-related cognitive decline', Trends in Endocrinology & Metabolism, vol. 33, no. 1, pp. 50-71. https://doi.org/10.1016/j.tem.2021.10.008

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T1 - Common pathways in dementia and diabetic retinopathy: understanding the mechanisms of diabetes-related cognitive decline

AU - Little, Karis

AU - Llorián-Salvador, María

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AU - Simó-Servat, Olga

AU - Del Marco, Angel

AU - Bosma, Esmeralda

AU - Vargas-Soria, Maria

AU - Carranza-Naval, Maria Jose

AU - Galbiati, Silvia

AU - Viganò, Ilaria

AU - Musi, Clara Alice

AU - Schlingemann, Reiner

AU - Feyen, Jean

AU - Borsello, Tiziana

AU - Zerbini, Gianpaolo

AU - Klaassen, Ingeborg

AU - Garcia-Alloza, Monica

AU - Simó, Rafael

AU - Stitt, Alan W

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N2 - Type 2 diabetes (T2D) is associated with multiple comorbidities, including diabetic retinopathy (DR) and cognitive decline, and T2D patients have a significantly higher risk of developing Alzheimer's disease (AD). Both DR and AD are characterized by a number of pathological mechanisms that coalesce around the neurovascular unit, including neuroinflammation and degeneration, vascular degeneration, and glial activation. Chronic hyperglycemia and insulin resistance also play a significant role, leading to activation of pathological mechanisms such as increased oxidative stress and the accumulation of advanced glycation end-products (AGEs). Understanding these common pathways and the degree to which they occur simultaneously in the brain and retina during diabetes will provide avenues to identify T2D patients at risk of cognitive decline.

AB - Type 2 diabetes (T2D) is associated with multiple comorbidities, including diabetic retinopathy (DR) and cognitive decline, and T2D patients have a significantly higher risk of developing Alzheimer's disease (AD). Both DR and AD are characterized by a number of pathological mechanisms that coalesce around the neurovascular unit, including neuroinflammation and degeneration, vascular degeneration, and glial activation. Chronic hyperglycemia and insulin resistance also play a significant role, leading to activation of pathological mechanisms such as increased oxidative stress and the accumulation of advanced glycation end-products (AGEs). Understanding these common pathways and the degree to which they occur simultaneously in the brain and retina during diabetes will provide avenues to identify T2D patients at risk of cognitive decline.

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JO - Trends in Endocrinology & Metabolism

JF - Trends in Endocrinology & Metabolism

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ER -

Common pathways in dementia and diabetic retinopathy: understanding the mechanisms of diabetes-related cognitive decline

Abstract

Bibliographical note

UN SDGs

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