Common polymorphisms of Fibulin-5 and the risk of abdominal aortic aneurysm development

Stephen A. Badger; Chee V. Soong; Mark E. O'Donnell; Mohammed A. Sharif; Ragai R. Makar; Anne E. Hughes

doi:10.1177/1358863X09355667

Common polymorphisms of Fibulin-5 and the risk of abdominal aortic aneurysm development

Stephen A. Badger, Chee V. Soong, Mark E. O'Donnell, Mohammed A. Sharif, Ragai R. Makar, Anne E. Hughes

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

Fibulin-5 is a crucial protein in the connective tissue structure of the aortic wall. The purpose of this study was to determine if genetic variation within the Fibulin-5 gene was associated with abdominal aortic aneurysms (AAA). AAA patients, with disease-free controls, were recruited and a past medical history questionnaire completed. Three single nucleotide polymorphisms (SNPs) in the FBLN5 gene (rs2498834, rs2430366 and rs2254320) were genotyped. The two cohorts were compared and haplotype analysis performed. A total of 230 AAA cases and 278 controls were successfully genotyped. The mean age was 71.9 years (± 6.8). No difference between cases and controls was found in the distribution of alleles of FBLN5 SNPs rs2498834 (p = 0.47), rs2430366 (p = 0.45) or rs2254320 (p = 0.46). Haplotype analysis did not reveal any significant difference. In conclusion, genetic variation within FBLN5 is unlikely to play any role in the development of AAA.

Original language	English
Pages (from-to)	113-117
Number of pages	5
Journal	Vascular Medicine
Volume	15
Issue number	2
Early online date	04 Feb 2010
DOIs	https://doi.org/10.1177/1358863X09355667
Publication status	Published - 01 Apr 2010

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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Cite this

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title = "Common polymorphisms of Fibulin-5 and the risk of abdominal aortic aneurysm development",

abstract = "Fibulin-5 is a crucial protein in the connective tissue structure of the aortic wall. The purpose of this study was to determine if genetic variation within the Fibulin-5 gene was associated with abdominal aortic aneurysms (AAA). AAA patients, with disease-free controls, were recruited and a past medical history questionnaire completed. Three single nucleotide polymorphisms (SNPs) in the FBLN5 gene (rs2498834, rs2430366 and rs2254320) were genotyped. The two cohorts were compared and haplotype analysis performed. A total of 230 AAA cases and 278 controls were successfully genotyped. The mean age was 71.9 years (± 6.8). No difference between cases and controls was found in the distribution of alleles of FBLN5 SNPs rs2498834 (p = 0.47), rs2430366 (p = 0.45) or rs2254320 (p = 0.46). Haplotype analysis did not reveal any significant difference. In conclusion, genetic variation within FBLN5 is unlikely to play any role in the development of AAA.",

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T1 - Common polymorphisms of Fibulin-5 and the risk of abdominal aortic aneurysm development

AU - Badger, Stephen A.

AU - Soong, Chee V.

AU - O'Donnell, Mark E.

AU - Sharif, Mohammed A.

AU - Makar, Ragai R.

AU - Hughes, Anne E.

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Fibulin-5 is a crucial protein in the connective tissue structure of the aortic wall. The purpose of this study was to determine if genetic variation within the Fibulin-5 gene was associated with abdominal aortic aneurysms (AAA). AAA patients, with disease-free controls, were recruited and a past medical history questionnaire completed. Three single nucleotide polymorphisms (SNPs) in the FBLN5 gene (rs2498834, rs2430366 and rs2254320) were genotyped. The two cohorts were compared and haplotype analysis performed. A total of 230 AAA cases and 278 controls were successfully genotyped. The mean age was 71.9 years (± 6.8). No difference between cases and controls was found in the distribution of alleles of FBLN5 SNPs rs2498834 (p = 0.47), rs2430366 (p = 0.45) or rs2254320 (p = 0.46). Haplotype analysis did not reveal any significant difference. In conclusion, genetic variation within FBLN5 is unlikely to play any role in the development of AAA.

AB - Fibulin-5 is a crucial protein in the connective tissue structure of the aortic wall. The purpose of this study was to determine if genetic variation within the Fibulin-5 gene was associated with abdominal aortic aneurysms (AAA). AAA patients, with disease-free controls, were recruited and a past medical history questionnaire completed. Three single nucleotide polymorphisms (SNPs) in the FBLN5 gene (rs2498834, rs2430366 and rs2254320) were genotyped. The two cohorts were compared and haplotype analysis performed. A total of 230 AAA cases and 278 controls were successfully genotyped. The mean age was 71.9 years (± 6.8). No difference between cases and controls was found in the distribution of alleles of FBLN5 SNPs rs2498834 (p = 0.47), rs2430366 (p = 0.45) or rs2254320 (p = 0.46). Haplotype analysis did not reveal any significant difference. In conclusion, genetic variation within FBLN5 is unlikely to play any role in the development of AAA.

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SP - 113

EP - 117

JO - Vascular Medicine

JF - Vascular Medicine

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Common polymorphisms of Fibulin-5 and the risk of abdominal aortic aneurysm development

Abstract

ASJC Scopus subject areas

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