Comorbidities and current smoking status amongst patients starting renal replacement therapy in England, Wales and Northern Ireland: national and centre-specific analyses

U. Udayaraj, C.R.V. Tomson, J. Gilg, D. Ansell, Damian Fogarty

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

8 Citations (Scopus)

Abstract

Introduction: The prevalence of 13 comorbid conditions and smoking status at the time of starting renal replacement therapy (RRT) in England, Wales and Northern Ireland are described. Methods: Adult patients starting RRT between 2002 and 2007 in centres reporting to the UK Renal Registry (UKRR) and with data on comorbidity (n¼13,293) were included. The association of comorbidity with patient demographics, treatment modality, haemoglobin, renal function at start of RRT and subsequent listing for kidney transplantation were studied. Association between comorbidities and mortality at 90 days and one year after 90 days from start of RRT was explored using Cox regression. Results: Completeness of data on comorbidity returned to the UKRR remained poor. Of patients with data, 52% had one or more comorbidities. Diabetes mellitus and ischaemic heart disease were the most common conditions seen in 28.9% and 22.5% of patients respectively. Comorbidities became more common with increasing age (up to the 65–74 age group), were more common amongst Whites and were associated with a lower likelihood of pre-emptive transplantation, a greater likelihood of starting on haemodialysis (rather than peritoneal dialysis) and a lower likelihood of being listed for kidney transplantation. In multivariable survival analysis, malignancy and ischaemic/neuropathic ulcers were the strongest predictors of poor survival at 1 year after 90 days from start of RRT. Conclusions: The majority of patients had at least one comorbid condition and comorbidity is an important predictor of early mortality on RRT.
Original languageEnglish
Title of host publicationUK Renal Registry 11th Annual Report (December 2008)
PublisherKarger
Pagesc97-c111
Number of pages15
Volume111
DOIs
Publication statusPublished - 2009

Publication series

NameNephron Clinical Practice
PublisherKarger
Volume111

Fingerprint

Northern Ireland
Renal Replacement Therapy
Wales
England
Comorbidity
Smoking
Kidney
Registries
Transplantation
Mortality
Survival Analysis
Kidney Transplantation
Ulcer
Myocardial Ischemia
Renal Dialysis
Hemoglobins
Age Groups
Demography
Survival
Neoplasms

Cite this

Udayaraj, U., Tomson, C. R. V., Gilg, J., Ansell, D., & Fogarty, D. (2009). Comorbidities and current smoking status amongst patients starting renal replacement therapy in England, Wales and Northern Ireland: national and centre-specific analyses. In UK Renal Registry 11th Annual Report (December 2008) (Vol. 111, pp. c97-c111). (Nephron Clinical Practice; Vol. 111). Karger. https://doi.org/10.1159/000209995
Udayaraj, U. ; Tomson, C.R.V. ; Gilg, J. ; Ansell, D. ; Fogarty, Damian. / Comorbidities and current smoking status amongst patients starting renal replacement therapy in England, Wales and Northern Ireland: national and centre-specific analyses. UK Renal Registry 11th Annual Report (December 2008) . Vol. 111 Karger, 2009. pp. c97-c111 (Nephron Clinical Practice).
@inbook{7d9eea4627ae4e04924a94609130151f,
title = "Comorbidities and current smoking status amongst patients starting renal replacement therapy in England, Wales and Northern Ireland: national and centre-specific analyses",
abstract = "Introduction: The prevalence of 13 comorbid conditions and smoking status at the time of starting renal replacement therapy (RRT) in England, Wales and Northern Ireland are described. Methods: Adult patients starting RRT between 2002 and 2007 in centres reporting to the UK Renal Registry (UKRR) and with data on comorbidity (n¼13,293) were included. The association of comorbidity with patient demographics, treatment modality, haemoglobin, renal function at start of RRT and subsequent listing for kidney transplantation were studied. Association between comorbidities and mortality at 90 days and one year after 90 days from start of RRT was explored using Cox regression. Results: Completeness of data on comorbidity returned to the UKRR remained poor. Of patients with data, 52{\%} had one or more comorbidities. Diabetes mellitus and ischaemic heart disease were the most common conditions seen in 28.9{\%} and 22.5{\%} of patients respectively. Comorbidities became more common with increasing age (up to the 65–74 age group), were more common amongst Whites and were associated with a lower likelihood of pre-emptive transplantation, a greater likelihood of starting on haemodialysis (rather than peritoneal dialysis) and a lower likelihood of being listed for kidney transplantation. In multivariable survival analysis, malignancy and ischaemic/neuropathic ulcers were the strongest predictors of poor survival at 1 year after 90 days from start of RRT. Conclusions: The majority of patients had at least one comorbid condition and comorbidity is an important predictor of early mortality on RRT.",
author = "U. Udayaraj and C.R.V. Tomson and J. Gilg and D. Ansell and Damian Fogarty",
year = "2009",
doi = "10.1159/000209995",
language = "English",
volume = "111",
series = "Nephron Clinical Practice",
publisher = "Karger",
pages = "c97--c111",
booktitle = "UK Renal Registry 11th Annual Report (December 2008)",

}

Udayaraj, U, Tomson, CRV, Gilg, J, Ansell, D & Fogarty, D 2009, Comorbidities and current smoking status amongst patients starting renal replacement therapy in England, Wales and Northern Ireland: national and centre-specific analyses. in UK Renal Registry 11th Annual Report (December 2008) . vol. 111, Nephron Clinical Practice, vol. 111, Karger, pp. c97-c111. https://doi.org/10.1159/000209995

Comorbidities and current smoking status amongst patients starting renal replacement therapy in England, Wales and Northern Ireland: national and centre-specific analyses. / Udayaraj, U.; Tomson, C.R.V.; Gilg, J.; Ansell, D.; Fogarty, Damian.

UK Renal Registry 11th Annual Report (December 2008) . Vol. 111 Karger, 2009. p. c97-c111 (Nephron Clinical Practice; Vol. 111).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

TY - CHAP

T1 - Comorbidities and current smoking status amongst patients starting renal replacement therapy in England, Wales and Northern Ireland: national and centre-specific analyses

AU - Udayaraj, U.

AU - Tomson, C.R.V.

AU - Gilg, J.

AU - Ansell, D.

AU - Fogarty, Damian

PY - 2009

Y1 - 2009

N2 - Introduction: The prevalence of 13 comorbid conditions and smoking status at the time of starting renal replacement therapy (RRT) in England, Wales and Northern Ireland are described. Methods: Adult patients starting RRT between 2002 and 2007 in centres reporting to the UK Renal Registry (UKRR) and with data on comorbidity (n¼13,293) were included. The association of comorbidity with patient demographics, treatment modality, haemoglobin, renal function at start of RRT and subsequent listing for kidney transplantation were studied. Association between comorbidities and mortality at 90 days and one year after 90 days from start of RRT was explored using Cox regression. Results: Completeness of data on comorbidity returned to the UKRR remained poor. Of patients with data, 52% had one or more comorbidities. Diabetes mellitus and ischaemic heart disease were the most common conditions seen in 28.9% and 22.5% of patients respectively. Comorbidities became more common with increasing age (up to the 65–74 age group), were more common amongst Whites and were associated with a lower likelihood of pre-emptive transplantation, a greater likelihood of starting on haemodialysis (rather than peritoneal dialysis) and a lower likelihood of being listed for kidney transplantation. In multivariable survival analysis, malignancy and ischaemic/neuropathic ulcers were the strongest predictors of poor survival at 1 year after 90 days from start of RRT. Conclusions: The majority of patients had at least one comorbid condition and comorbidity is an important predictor of early mortality on RRT.

AB - Introduction: The prevalence of 13 comorbid conditions and smoking status at the time of starting renal replacement therapy (RRT) in England, Wales and Northern Ireland are described. Methods: Adult patients starting RRT between 2002 and 2007 in centres reporting to the UK Renal Registry (UKRR) and with data on comorbidity (n¼13,293) were included. The association of comorbidity with patient demographics, treatment modality, haemoglobin, renal function at start of RRT and subsequent listing for kidney transplantation were studied. Association between comorbidities and mortality at 90 days and one year after 90 days from start of RRT was explored using Cox regression. Results: Completeness of data on comorbidity returned to the UKRR remained poor. Of patients with data, 52% had one or more comorbidities. Diabetes mellitus and ischaemic heart disease were the most common conditions seen in 28.9% and 22.5% of patients respectively. Comorbidities became more common with increasing age (up to the 65–74 age group), were more common amongst Whites and were associated with a lower likelihood of pre-emptive transplantation, a greater likelihood of starting on haemodialysis (rather than peritoneal dialysis) and a lower likelihood of being listed for kidney transplantation. In multivariable survival analysis, malignancy and ischaemic/neuropathic ulcers were the strongest predictors of poor survival at 1 year after 90 days from start of RRT. Conclusions: The majority of patients had at least one comorbid condition and comorbidity is an important predictor of early mortality on RRT.

U2 - 10.1159/000209995

DO - 10.1159/000209995

M3 - Chapter (peer-reviewed)

VL - 111

T3 - Nephron Clinical Practice

SP - c97-c111

BT - UK Renal Registry 11th Annual Report (December 2008)

PB - Karger

ER -

Udayaraj U, Tomson CRV, Gilg J, Ansell D, Fogarty D. Comorbidities and current smoking status amongst patients starting renal replacement therapy in England, Wales and Northern Ireland: national and centre-specific analyses. In UK Renal Registry 11th Annual Report (December 2008) . Vol. 111. Karger. 2009. p. c97-c111. (Nephron Clinical Practice). https://doi.org/10.1159/000209995