Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins

Wenguang Shao, Tiannan Guo, Nora C. Toussaint, Peng Xue, Ulrich Wagner, Li Li, Konstantina Charmpi, Yi Zhu, Jianmin Wu, Marija Buljan, Rui Sun, Dorothea Rutishauser, Thomas Hermanns, Christian Daniel Fankhauser, Cedric Poyet, Jelena Ljubicic, Niels Rupp, Jan H. Rüschoff, Qing Zhong, Andreas BeyerJiafu Ji, Ben C. Collins, Yansheng Liu, Gunnar Rätsch, Peter J. Wild, Ruedi Aebersold

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)
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Abstract

Protein degradation in clinical samples is largely unexplored. Here, the authors analyze the transcriptome and proteome of clinical tissue samples and develop an algorithm to assess protein degradation, showing that protein degradation is negligible in most tissue samples and does not correlate with transcript degradation.
Original languageEnglish
JournalNature Communications
Volume10
Issue number1
DOIs
Publication statusPublished - 07 Jun 2019

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