Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins

Wenguang Shao; Tiannan Guo; Nora C. Toussaint; Peng Xue; Ulrich Wagner; Li Li; Konstantina Charmpi; Yi Zhu; Jianmin Wu; Marija Buljan; Rui Sun; Dorothea Rutishauser; Thomas Hermanns; Christian Daniel Fankhauser; Cedric Poyet; Jelena Ljubicic; Niels Rupp; Jan H. Rüschoff; Qing Zhong; Andreas Beyer; Jiafu Ji; Ben C. Collins; Yansheng Liu; Gunnar Rätsch; Peter J. Wild; Ruedi Aebersold

doi:10.1038/s41467-019-10513-5

Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins

Wenguang Shao, Tiannan Guo, Nora C. Toussaint, Peng Xue, Ulrich Wagner, Li Li, Konstantina Charmpi, Yi Zhu, Jianmin Wu, Marija Buljan, Rui Sun, Dorothea Rutishauser, Thomas Hermanns, Christian Daniel Fankhauser, Cedric Poyet, Jelena Ljubicic, Niels Rupp, Jan H. Rüschoff, Qing Zhong, Andreas BeyerJiafu Ji, Ben C. Collins, Yansheng Liu, Gunnar Rätsch, Peter J. Wild, Ruedi Aebersold

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Abstract

Protein degradation in clinical samples is largely unexplored. Here, the authors analyze the transcriptome and proteome of clinical tissue samples and develop an algorithm to assess protein degradation, showing that protein degradation is negligible in most tissue samples and does not correlate with transcript degradation.

Original language	English
Journal	Nature Communications
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41467-019-10513-5
Publication status	Published - 07 Jun 2019

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Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins
Copyright 2019 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
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Shao, W., Guo, T., Toussaint, N. C., Xue, P., Wagner, U., Li, L., Charmpi, K., Zhu, Y., Wu, J., Buljan, M., Sun, R., Rutishauser, D., Hermanns, T., Fankhauser, C. D., Poyet, C., Ljubicic, J., Rupp, N., Rüschoff, J. H., Zhong, Q., ... Aebersold, R. (2019). Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins. Nature Communications, 10(1). https://doi.org/10.1038/s41467-019-10513-5

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title = "Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins",

abstract = "Protein degradation in clinical samples is largely unexplored. Here, the authors analyze the transcriptome and proteome of clinical tissue samples and develop an algorithm to assess protein degradation, showing that protein degradation is negligible in most tissue samples and does not correlate with transcript degradation.",

author = "Wenguang Shao and Tiannan Guo and Toussaint, {Nora C.} and Peng Xue and Ulrich Wagner and Li Li and Konstantina Charmpi and Yi Zhu and Jianmin Wu and Marija Buljan and Rui Sun and Dorothea Rutishauser and Thomas Hermanns and Fankhauser, {Christian Daniel} and Cedric Poyet and Jelena Ljubicic and Niels Rupp and R{\"u}schoff, {Jan H.} and Qing Zhong and Andreas Beyer and Jiafu Ji and Collins, {Ben C.} and Yansheng Liu and Gunnar R{\"a}tsch and Wild, {Peter J.} and Ruedi Aebersold",

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doi = "10.1038/s41467-019-10513-5",

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Shao, W, Guo, T, Toussaint, NC, Xue, P, Wagner, U, Li, L, Charmpi, K, Zhu, Y, Wu, J, Buljan, M, Sun, R, Rutishauser, D, Hermanns, T, Fankhauser, CD, Poyet, C, Ljubicic, J, Rupp, N, Rüschoff, JH, Zhong, Q, Beyer, A, Ji, J, Collins, BC, Liu, Y, Rätsch, G, Wild, PJ & Aebersold, R 2019, 'Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins', Nature Communications, vol. 10, no. 1. https://doi.org/10.1038/s41467-019-10513-5

TY - JOUR

T1 - Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins

AU - Shao, Wenguang

AU - Guo, Tiannan

AU - Toussaint, Nora C.

AU - Xue, Peng

AU - Wagner, Ulrich

AU - Li, Li

AU - Charmpi, Konstantina

AU - Zhu, Yi

AU - Wu, Jianmin

AU - Buljan, Marija

AU - Sun, Rui

AU - Rutishauser, Dorothea

AU - Hermanns, Thomas

AU - Fankhauser, Christian Daniel

AU - Poyet, Cedric

AU - Ljubicic, Jelena

AU - Rupp, Niels

AU - Rüschoff, Jan H.

AU - Zhong, Qing

AU - Beyer, Andreas

AU - Ji, Jiafu

AU - Collins, Ben C.

AU - Liu, Yansheng

AU - Rätsch, Gunnar

AU - Wild, Peter J.

AU - Aebersold, Ruedi

PY - 2019/6/7

Y1 - 2019/6/7

N2 - Protein degradation in clinical samples is largely unexplored. Here, the authors analyze the transcriptome and proteome of clinical tissue samples and develop an algorithm to assess protein degradation, showing that protein degradation is negligible in most tissue samples and does not correlate with transcript degradation.

AB - Protein degradation in clinical samples is largely unexplored. Here, the authors analyze the transcriptome and proteome of clinical tissue samples and develop an algorithm to assess protein degradation, showing that protein degradation is negligible in most tissue samples and does not correlate with transcript degradation.

U2 - 10.1038/s41467-019-10513-5

DO - 10.1038/s41467-019-10513-5

M3 - Article

SN - 2041-1723

VL - 10

JO - Nature Communications

JF - Nature Communications

IS - 1

ER -

Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins

Abstract

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