Comparison of 10,11‐Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs

Rachel Cochrane; Zhizeng Gao; Gareth Lambkin; Wei Xu; Jaclyn Winter; Sandra Marcus; Yi Tang; John Vederas

doi:10.1002/cbic.201500428

Comparison of 10,11‐Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs

Rachel Cochrane, Zhizeng Gao, Gareth Lambkin, Wei Xu, Jaclyn Winter, Sandra Marcus, Yi Tang, John Vederas^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

DHC keys: We have identified and heterologously expressed two iterative type I polyketide synthases necessary to produce the phytotoxic anticancer agent 10,11‐dehydrocurvularin (DHC) in A. cinerariae. This allowed bioinformatic comparison to the analogous metabolite gene cluster in A. terreus, which highlighted key structural features necessary for metabolite production.

Original language	English
Pages (from-to)	2479
Number of pages	2483
Journal	ChemBioChem
Volume	16
DOIs	https://doi.org/10.1002/cbic.201500428
Publication status	Published - 23 Oct 2015

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title = "Comparison of 10,11‐Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs",

abstract = "DHC keys: We have identified and heterologously expressed two iterative type I polyketide synthases necessary to produce the phytotoxic anticancer agent 10,11‐dehydrocurvularin (DHC) in A. cinerariae. This allowed bioinformatic comparison to the analogous metabolite gene cluster in A. terreus, which highlighted key structural features necessary for metabolite production.",

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T1 - Comparison of 10,11‐Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs

AU - Cochrane, Rachel

AU - Gao, Zhizeng

AU - Lambkin, Gareth

AU - Xu, Wei

AU - Winter, Jaclyn

AU - Marcus, Sandra

AU - Tang, Yi

AU - Vederas, John

PY - 2015/10/23

Y1 - 2015/10/23

N2 - DHC keys: We have identified and heterologously expressed two iterative type I polyketide synthases necessary to produce the phytotoxic anticancer agent 10,11‐dehydrocurvularin (DHC) in A. cinerariae. This allowed bioinformatic comparison to the analogous metabolite gene cluster in A. terreus, which highlighted key structural features necessary for metabolite production.

AB - DHC keys: We have identified and heterologously expressed two iterative type I polyketide synthases necessary to produce the phytotoxic anticancer agent 10,11‐dehydrocurvularin (DHC) in A. cinerariae. This allowed bioinformatic comparison to the analogous metabolite gene cluster in A. terreus, which highlighted key structural features necessary for metabolite production.

U2 - 10.1002/cbic.201500428

DO - 10.1002/cbic.201500428

M3 - Article

SN - 1439-4227

VL - 16

SP - 2479

JO - ChemBioChem

JF - ChemBioChem

ER -

Comparison of 10,11‐Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs

Abstract

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