Comparison of 10,11‐Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs

Rachel Cochrane, Zhizeng Gao, Gareth Lambkin, Wei Xu, Jaclyn Winter, Sandra Marcus, Yi Tang, John Vederas*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

DHC keys: We have identified and heterologously expressed two iterative type I polyketide synthases necessary to produce the phytotoxic anticancer agent 10,11‐dehydrocurvularin (DHC) in A. cinerariae. This allowed bioinformatic comparison to the analogous metabolite gene cluster in A. terreus, which highlighted key structural features necessary for metabolite production.
Original languageEnglish
Pages (from-to)2479
Number of pages2483
JournalChemBioChem
Volume16
DOIs
Publication statusPublished - 23 Oct 2015

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