Complement inhibitors for age-related macular degeneration

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Abstract

Given the relatively high prevalence of age-related macular degeneration (AMD) and the increased incidence of AMD as populations age, the results of trials of novel treatments are awaited with much anticipation. The complement cascade describes a series of proteolytic reactions occurring throughout the body that generate proteins with a variety of roles including the initiation and promotion of immune reactions against foreign materials or micro-organisms. The complement cascade is normally tightly regulated, but much evidence implicates complement overactivity in AMD and so it is a logical therapeutic target in the treatment of AMD.
Original languageEnglish
Article numberCD009300
Number of pages20
JournalCochrane Database of Systematic Reviews
Issue number1
DOIs
Publication statusPublished - 15 Jan 2014

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