Complex roles of TGF-b signaling pathways in lung development and bronchopulmonary dysplasia

Rebecca J. Calthorpe; Caroline Poulter; Alan R. Smyth; Don Sharkey; Jayesh Bhatt; Gisli Jenkins; Amanda L. Tatler

doi:10.1152/ajplung.00106.2021

Complex roles of TGF-b signaling pathways in lung development and bronchopulmonary dysplasia

Rebecca J. Calthorpe, Caroline Poulter, Alan R. Smyth, Don Sharkey, Jayesh Bhatt, Gisli Jenkins^*, Amanda L. Tatler^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

12 Citations (Scopus)

17 Downloads (Pure)

Abstract

As survival of extremely preterm infants continues to improve, there is also an associated increase in bronchopulmonary dysplasia (BPD), one of the most significant complications of preterm birth. BPD development is multifactorial resulting from exposure to multiple antenatal and postnatal stressors. BPD has both short-term health implications and long-term sequelae including increased respiratory, cardiovascular, and neurological morbidity. Transforming growth factor b (TGF-b) is an important signaling pathway in lung development, organ injury, and fibrosis and is implicated in the development of BPD. This review provides a detailed account on the role of TGF-b in antenatal and postnatal lung development, the effect of known risk factors for BPD on the TGF-b signaling pathway, and how medications currently in use or under development, for the prevention or treatment of BPD, affect TGF-b signaling.

Original language	English
Pages (from-to)	L285-L296
Number of pages	12
Journal	American Journal of Physiology - Lung Cellular and Molecular Physiology
Volume	324
Issue number	3
Early online date	10 Jan 2023
DOIs	https://doi.org/10.1152/ajplung.00106.2021
Publication status	Published - Mar 2023
Externally published	Yes

Bibliographical note

Funding Information:
A.R.S has research grants (paid to the University of Nottingham) from Vertex Pharmaceuticals and payment for an advisory board (paid to the University of Nottingham) from Viatris Pharmaceuticals, all outside the current work. A.R.S. has patents issued (Camara M, Williams P, Barrett D, Halliday N, Knox A, Smyth A, Fogarty A, Barr H, Forrester D. Alkyl quinolones as biomarkers of Pseudomonas aeruginosa infection and uses thereof. US2016131648-A1; https://pubchem. ncbi.nlm.nih.gov/patent/US-2016131648-A1). Outside the current work, A.R.S reports participation on a Data Safety Monitoring Board for the North American Cystic Fibrosis Foundation Therapeutic Development Network. R.J.C. was previously supported by a National Institute for Health Research (NIHR) Academic Clinical Fellowship. G.J. reports personal fees and other from Biogen, personal fees from Galapagos, other from Galecto, personal fees and other from GlaxoSmithKline, personal fees from Heptares, personal fees and other from MedImmune, personal fees from Boehringer Ingelheim, personal fees from Pliant, personal fees from Roche/ InterMune, personal fees from PharmAkea, personal fees from Bristol Myers Squibb, personal fees from Chiesi, personal fees from Roche/Promedior, other from RedX, other from NuMedii, other from Nordic Biosciences, personal fees from Veracyte, outside the submitted work. G.J. is supported by a National Institute of Health Research Professorship and is a trustee for Action for Pulmonary Fibrosis. A.L.T. reports consulting for biotech.

Funding Information:
This work was supported in part by Medical Research Foundation Grant MRF-091-0004-RG-TATLE to A.L.T. and by a National Institute for Health and Care Research (NIHR) Academic Clinical Fellowship to R.J.C.

Publisher Copyright:
© 2023 Journal of medical pharmaceutical and allied sciences. All rights reserved.

Keywords

bronchopulmonary dysplasia
transforming growth factor-b

ASJC Scopus subject areas

Physiology
Pulmonary and Respiratory Medicine
Physiology (medical)
Cell Biology

Access to Document

10.1152/ajplung.00106.2021Licence: CC BY

Complex roles of TGF-β signaling pathways in lung development and bronchopulmonary dysplasia
Copyright 2023 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 927 KBLicence: CC BY

Cite this

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title = "Complex roles of TGF-b signaling pathways in lung development and bronchopulmonary dysplasia",

abstract = "As survival of extremely preterm infants continues to improve, there is also an associated increase in bronchopulmonary dysplasia (BPD), one of the most significant complications of preterm birth. BPD development is multifactorial resulting from exposure to multiple antenatal and postnatal stressors. BPD has both short-term health implications and long-term sequelae including increased respiratory, cardiovascular, and neurological morbidity. Transforming growth factor b (TGF-b) is an important signaling pathway in lung development, organ injury, and fibrosis and is implicated in the development of BPD. This review provides a detailed account on the role of TGF-b in antenatal and postnatal lung development, the effect of known risk factors for BPD on the TGF-b signaling pathway, and how medications currently in use or under development, for the prevention or treatment of BPD, affect TGF-b signaling.",

keywords = "bronchopulmonary dysplasia, transforming growth factor-b",

author = "Calthorpe, {Rebecca J.} and Caroline Poulter and Smyth, {Alan R.} and Don Sharkey and Jayesh Bhatt and Gisli Jenkins and Tatler, {Amanda L.}",

note = "Funding Information: A.R.S has research grants (paid to the University of Nottingham) from Vertex Pharmaceuticals and payment for an advisory board (paid to the University of Nottingham) from Viatris Pharmaceuticals, all outside the current work. A.R.S. has patents issued (Camara M, Williams P, Barrett D, Halliday N, Knox A, Smyth A, Fogarty A, Barr H, Forrester D. Alkyl quinolones as biomarkers of Pseudomonas aeruginosa infection and uses thereof. US2016131648-A1; https://pubchem. ncbi.nlm.nih.gov/patent/US-2016131648-A1). Outside the current work, A.R.S reports participation on a Data Safety Monitoring Board for the North American Cystic Fibrosis Foundation Therapeutic Development Network. R.J.C. was previously supported by a National Institute for Health Research (NIHR) Academic Clinical Fellowship. G.J. reports personal fees and other from Biogen, personal fees from Galapagos, other from Galecto, personal fees and other from GlaxoSmithKline, personal fees from Heptares, personal fees and other from MedImmune, personal fees from Boehringer Ingelheim, personal fees from Pliant, personal fees from Roche/ InterMune, personal fees from PharmAkea, personal fees from Bristol Myers Squibb, personal fees from Chiesi, personal fees from Roche/Promedior, other from RedX, other from NuMedii, other from Nordic Biosciences, personal fees from Veracyte, outside the submitted work. G.J. is supported by a National Institute of Health Research Professorship and is a trustee for Action for Pulmonary Fibrosis. A.L.T. reports consulting for biotech. Funding Information: This work was supported in part by Medical Research Foundation Grant MRF-091-0004-RG-TATLE to A.L.T. and by a National Institute for Health and Care Research (NIHR) Academic Clinical Fellowship to R.J.C. Publisher Copyright: {\textcopyright} 2023 Journal of medical pharmaceutical and allied sciences. All rights reserved.",

year = "2023",

month = mar,

doi = "10.1152/ajplung.00106.2021",

language = "English",

volume = "324",

pages = "L285--L296",

journal = "American Journal of Physiology - Lung Cellular and Molecular Physiology",

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AU - Calthorpe, Rebecca J.

AU - Poulter, Caroline

AU - Smyth, Alan R.

AU - Sharkey, Don

AU - Bhatt, Jayesh

AU - Jenkins, Gisli

AU - Tatler, Amanda L.

N1 - Funding Information: A.R.S has research grants (paid to the University of Nottingham) from Vertex Pharmaceuticals and payment for an advisory board (paid to the University of Nottingham) from Viatris Pharmaceuticals, all outside the current work. A.R.S. has patents issued (Camara M, Williams P, Barrett D, Halliday N, Knox A, Smyth A, Fogarty A, Barr H, Forrester D. Alkyl quinolones as biomarkers of Pseudomonas aeruginosa infection and uses thereof. US2016131648-A1; https://pubchem. ncbi.nlm.nih.gov/patent/US-2016131648-A1). Outside the current work, A.R.S reports participation on a Data Safety Monitoring Board for the North American Cystic Fibrosis Foundation Therapeutic Development Network. R.J.C. was previously supported by a National Institute for Health Research (NIHR) Academic Clinical Fellowship. G.J. reports personal fees and other from Biogen, personal fees from Galapagos, other from Galecto, personal fees and other from GlaxoSmithKline, personal fees from Heptares, personal fees and other from MedImmune, personal fees from Boehringer Ingelheim, personal fees from Pliant, personal fees from Roche/ InterMune, personal fees from PharmAkea, personal fees from Bristol Myers Squibb, personal fees from Chiesi, personal fees from Roche/Promedior, other from RedX, other from NuMedii, other from Nordic Biosciences, personal fees from Veracyte, outside the submitted work. G.J. is supported by a National Institute of Health Research Professorship and is a trustee for Action for Pulmonary Fibrosis. A.L.T. reports consulting for biotech. Funding Information: This work was supported in part by Medical Research Foundation Grant MRF-091-0004-RG-TATLE to A.L.T. and by a National Institute for Health and Care Research (NIHR) Academic Clinical Fellowship to R.J.C. Publisher Copyright: © 2023 Journal of medical pharmaceutical and allied sciences. All rights reserved.

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N2 - As survival of extremely preterm infants continues to improve, there is also an associated increase in bronchopulmonary dysplasia (BPD), one of the most significant complications of preterm birth. BPD development is multifactorial resulting from exposure to multiple antenatal and postnatal stressors. BPD has both short-term health implications and long-term sequelae including increased respiratory, cardiovascular, and neurological morbidity. Transforming growth factor b (TGF-b) is an important signaling pathway in lung development, organ injury, and fibrosis and is implicated in the development of BPD. This review provides a detailed account on the role of TGF-b in antenatal and postnatal lung development, the effect of known risk factors for BPD on the TGF-b signaling pathway, and how medications currently in use or under development, for the prevention or treatment of BPD, affect TGF-b signaling.

AB - As survival of extremely preterm infants continues to improve, there is also an associated increase in bronchopulmonary dysplasia (BPD), one of the most significant complications of preterm birth. BPD development is multifactorial resulting from exposure to multiple antenatal and postnatal stressors. BPD has both short-term health implications and long-term sequelae including increased respiratory, cardiovascular, and neurological morbidity. Transforming growth factor b (TGF-b) is an important signaling pathway in lung development, organ injury, and fibrosis and is implicated in the development of BPD. This review provides a detailed account on the role of TGF-b in antenatal and postnatal lung development, the effect of known risk factors for BPD on the TGF-b signaling pathway, and how medications currently in use or under development, for the prevention or treatment of BPD, affect TGF-b signaling.

KW - bronchopulmonary dysplasia

KW - transforming growth factor-b

U2 - 10.1152/ajplung.00106.2021

DO - 10.1152/ajplung.00106.2021

M3 - Review article

C2 - 36625900

AN - SCOPUS:85150000667

SN - 1040-0605

VL - 324

SP - L285-L296

JO - American Journal of Physiology - Lung Cellular and Molecular Physiology

JF - American Journal of Physiology - Lung Cellular and Molecular Physiology

IS - 3

ER -

Complex roles of TGF-b signaling pathways in lung development and bronchopulmonary dysplasia

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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