Complex Signaling Networks Controlling Dynamic Molecular Changes in Pseudomonas aeruginosa Biofilm

Grzegorz Gula, Agata Dorotkiewicz-Jach, Kamila Korzekwa, Miguel Angel Valvano, Zuzanna Drulis-Kawa

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)
170 Downloads (Pure)


The environment exerts strong influence on microbes. Adaptation of microbes to changing conditions is a dynamic process regulated by complex networks. Pseudomonas aeruginosa is a life-threating, versatile opportunistic and multi drug resistant pathogen that provides a model to investigate adaptation mechanisms to environmental changes. The ability of P. aeruginosa to form biofilms and to modify virulence in response to environmental changes are coordinated by various mechanisms including two-component systems (TCS), and secondary messengers involved in quorum sensing (QS) and c-di-GMP networks (diguanylate cyclase systems, DGC). In this review, we focus on the role of c-di-GMP during biofilm formation. We describe TCS and QS signal cascades regulated by c-di-GMP in response to changes in the external environment. We present a complex signaling network dynamically changing during the transition of P. aeruginosa from the free-living to sessile mode of growth.

Original languageEnglish
Number of pages14
JournalCurrent medicinal chemistry
Early online date11 Sep 2018
Publication statusEarly online date - 11 Sep 2018
Externally publishedYes

Fingerprint Dive into the research topics of 'Complex Signaling Networks Controlling Dynamic Molecular Changes in Pseudomonas aeruginosa Biofilm'. Together they form a unique fingerprint.

Cite this