Concentrations of urinary arsenic species in relation to rice and seafood consumption among children living in Spain

Antonio J Signes-Pastor, Jesus Vioque, Eva M Navarrete-Muñoz, Manus Carey, Manoli García de la Hera, Jordi Sunyer, Maribel Casas, Isolina Riaño-Galán, Adonina Tardón, Sabrina Llop, Rubén Amorós, Pilar Amiano, José R Bilbao, Margaret R Karagas, Andrew A Meharg

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Abstract

Inorganic arsenic (i-As) has been related to wide-ranging health effects in children, leading to lifelong concerns. Proportionally, dietary i-As exposure dominates in regions with low arsenic drinking water. This study aims to investigate the relation between rice and seafood consumption and urinary arsenic species during childhood and to assess the proportion of urinary i-As metabolites. Urinary arsenic species concentration in 400 4-year-old children living in four geographical areas of Spain, in addition to repeated measures from 100 children at 7 years of age are included in this study. Rice and seafood products intake was collected from children's parents using a validated food frequency questionnaire (FFQ). At 4 years of age, children's urine i-As and monomethylarsonic acid (MMA) concentrations increased with rice product consumption (p-value = 0.010 and 0.018, respectively), and urinary arsenobetaine (AsB) with seafood consumption (p = 0.002). Four-year-old children had a higher consumption of both rice and seafood per body weight and a higher urinary %MMA (p-value = 0.001) and lower % dimethylarsinic acid (DMA) (p-value = 0.017). This study suggests increased dietary i-As exposure related to rice product consumption among children living in Spain, and the younger ones may be especially vulnerable to the health impacts of this exposure also considering that they might have a lower i-As methylation capacity than older children. In contrast, seafood consumption did not appear to influence the presence of potentially toxic arsenic species in this population of children.

Original languageEnglish
Pages (from-to)69-75
JournalEnvironmental Research
Volume159
DOIs
Publication statusPublished - 01 Aug 2017

Keywords

  • Arsenic
  • Child
  • Child, Preschool
  • Diet
  • Environmental Exposure
  • Environmental Monitoring
  • Environmental Pollutants
  • Female
  • Food Contamination
  • Humans
  • Male
  • Oryza
  • Seafood
  • Spain
  • Surveys and Questionnaires
  • Journal Article

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    Signes-Pastor, A. J., Vioque, J., Navarrete-Muñoz, E. M., Carey, M., García de la Hera, M., Sunyer, J., Casas, M., Riaño-Galán, I., Tardón, A., Llop, S., Amorós, R., Amiano, P., Bilbao, J. R., Karagas, M. R., & Meharg, A. A. (2017). Concentrations of urinary arsenic species in relation to rice and seafood consumption among children living in Spain. Environmental Research, 159, 69-75. https://doi.org/10.1016/j.envres.2017.07.046