Conserved hydrogen bonding in tetrahydrocarbazolone derivatives: influence of solution-state assembly on crystal form nucleation

Robert M. Edkins; Elliott Hayden; Jonathan W. Steed; Katharina Edkins

doi:10.1039/C4CC10453F

Conserved hydrogen bonding in tetrahydrocarbazolone derivatives: influence of solution-state assembly on crystal form nucleation

Robert M. Edkins, Elliott Hayden, Jonathan W. Steed, Katharina Edkins

School of Pharmacy

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6 Citations (Scopus)

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Abstract

Two tetrahydocarbazolone derivatives were found to show multiple unsolvated crystal forms. A persistent dimer motif was detected in solution by FTIR spectroscopy that is maintained in the kinetic crystal forms. Rationally introduced steric bulk induces the formation of a more stable catemeric form.

Original language	English
Pages (from-to)	5314-5317
Journal	Chemical Communications
Volume	51
Issue number	25
Early online date	17 Feb 2015
DOIs	https://doi.org/10.1039/C4CC10453F
Publication status	Published - 2015

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10.1039/C4CC10453FLicence: CC BY

c4cc10453f
© The Royal Society of Chemistry 2015. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 1.63 MBLicence: CC BY
Carbazolone ChemCommun final

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title = "Conserved hydrogen bonding in tetrahydrocarbazolone derivatives: influence of solution-state assembly on crystal form nucleation",

abstract = "Two tetrahydocarbazolone derivatives were found to show multiple unsolvated crystal forms. A persistent dimer motif was detected in solution by FTIR spectroscopy that is maintained in the kinetic crystal forms. Rationally introduced steric bulk induces the formation of a more stable catemeric form.",

author = "Edkins, {Robert M.} and Elliott Hayden and Steed, {Jonathan W.} and Katharina Edkins",

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AU - Hayden, Elliott

AU - Steed, Jonathan W.

AU - Edkins, Katharina

PY - 2015

Y1 - 2015

N2 - Two tetrahydocarbazolone derivatives were found to show multiple unsolvated crystal forms. A persistent dimer motif was detected in solution by FTIR spectroscopy that is maintained in the kinetic crystal forms. Rationally introduced steric bulk induces the formation of a more stable catemeric form.

AB - Two tetrahydocarbazolone derivatives were found to show multiple unsolvated crystal forms. A persistent dimer motif was detected in solution by FTIR spectroscopy that is maintained in the kinetic crystal forms. Rationally introduced steric bulk induces the formation of a more stable catemeric form.

U2 - 10.1039/C4CC10453F

DO - 10.1039/C4CC10453F

M3 - Article

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SP - 5314

EP - 5317

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 25

ER -

Conserved hydrogen bonding in tetrahydrocarbazolone derivatives: influence of solution-state assembly on crystal form nucleation

Abstract

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