Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

Mireia Obón-Santacana, Leila Luján-Barroso, Heinz Freisling, Sabine Naudin, Marie-Christine Boutron-Ruault, Francesca Romana Mancini, Vinciane Rebours, Tilman Kühn, Verena Katzke, Heiner Boeing, Anne Tjønneland, Anja Olsen, Kim Overvad, Cristina Lasheras, Miguel Rodríguez-Barranco, Pilar Amiano, Carmen Santiuste, Eva Ardanaz, Kay-Thee Khaw, Nicholas J WarehamJulie A Schmidt, Dagfinn Aune, Antonia Trichopoulou, Paschalis Thriskos, Eleni Peppa, Giovanna Masala, Sara Grioni, Rosario Tumino, Salvatore Panico, Bas Bueno-de-Mesquita, Veronica Sciannameo, Roel Vermeulen, Emily Sonestedt, Malin Sund, Elisabete Weiderpass, Guri Skeie, Carlos A González, Elio Riboli, Eric J Duell

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72-1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.

Original languageEnglish
Pages (from-to)76-84
Number of pages9
JournalInternational Journal of Cancer
Volume146
Issue number1
Early online date06 Jun 2019
DOIs
Publication statusPublished - 01 Jan 2020

Bibliographical note

© 2019 UICC.

Keywords

  • Carcinoma, Pancreatic Ductal/etiology
  • Diet
  • Europe
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nuts
  • Pancreatic Neoplasms/etiology
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Factors
  • Seeds
  • Surveys and Questionnaires

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