Continuous multi-step synthesis by extrusion – telescoping solvent-free reactions for greater efficiency

Deborah E. Crawford, Clodagh K. Miskimmin, John Cahir, Stuart James

Research output: Contribution to journalArticle

19 Citations (Scopus)
159 Downloads (Pure)


Chemical manufacturing typically requires more than one step, involving multiple batch processes, which makes synthesis at scale laborious and wasteful. Herein, we demonstrate that several reactions can be telescoped into a single continuous process and/or be carried out as a continuous multi-component reaction (MCR), by twin screw extrusion (TSE), in the complete absence of solvent.
Original languageEnglish
Pages (from-to)13067-13070
Number of pages4
JournalChemical Communications
Issue number97
Early online date10 Nov 2017
Publication statusPublished - 10 Nov 2017


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