Continuous multi-step synthesis by extrusion – telescoping solvent-free reactions for greater efficiency

Deborah E. Crawford; Clodagh K. Miskimmin; John Cahir; Stuart James

doi:10.1039/C7CC06010F

Continuous multi-step synthesis by extrusion – telescoping solvent-free reactions for greater efficiency

Deborah E. Crawford, Clodagh K. Miskimmin, John Cahir, Stuart James

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

292 Downloads (Pure)

Abstract

Chemical manufacturing typically requires more than one step, involving multiple batch processes, which makes synthesis at scale laborious and wasteful. Herein, we demonstrate that several reactions can be telescoped into a single continuous process and/or be carried out as a continuous multi-component reaction (MCR), by twin screw extrusion (TSE), in the complete absence of solvent.

Original language	English
Pages (from-to)	13067-13070
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	97
Early online date	10 Nov 2017
DOIs	https://doi.org/10.1039/C7CC06010F
Publication status	Published - 10 Nov 2017

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Continuous multi-step synthesis by extrusion - telescoping solvent-free reactions for greater efficiency
© The Royal Society of Chemistry 2017. This work is made available online in accordance with the publisher’s policies. Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 534 KBLicence: Unspecified

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abstract = "Chemical manufacturing typically requires more than one step, involving multiple batch processes, which makes synthesis at scale laborious and wasteful. Herein, we demonstrate that several reactions can be telescoped into a single continuous process and/or be carried out as a continuous multi-component reaction (MCR), by twin screw extrusion (TSE), in the complete absence of solvent.",

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AB - Chemical manufacturing typically requires more than one step, involving multiple batch processes, which makes synthesis at scale laborious and wasteful. Herein, we demonstrate that several reactions can be telescoped into a single continuous process and/or be carried out as a continuous multi-component reaction (MCR), by twin screw extrusion (TSE), in the complete absence of solvent.

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Continuous multi-step synthesis by extrusion – telescoping solvent-free reactions for greater efficiency

Abstract

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