Chemical manufacturing typically requires more than one step, involving multiple batch processes, which makes synthesis at scale laborious and wasteful. Herein, we demonstrate that several reactions can be telescoped into a single continuous process and/or be carried out as a continuous multi-component reaction (MCR), by twin screw extrusion (TSE), in the complete absence of solvent.
Crawford, D. E., Miskimmin, C. K., Cahir, J., & James, S. (2017). Continuous multi-step synthesis by extrusion – telescoping solvent-free reactions for greater efficiency. Chemical Communications, 53(97), 13067-13070. https://doi.org/10.1039/C7CC06010F