Contributions of neutrophils to resolution of mucosal inflammation

Sean P. Colgan*, Stefan F. Ehrentraut, Louise E. Glover, Douglas J. Kominsky, Eric L. Campbell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Neutrophil (PMN) recruitment from the blood stream into surrounding tissues involves a regulated series of events central to acute responses in host defense. Accumulation of PMN within mucosal tissues has historically been considered pathognomonic features of both acute and chronic inflammatory conditions. Historically, PMNs have been deemed necessary but detrimental when recruited, given the potential for tissue damage that results from a variety of mechanisms. Recent work, however, has altered our preconceived notions of PMN contributions to inflammatory processes. In particular, significant evidence implicates a central role for the PMN in triggering inflammatory resolution. Such mechanisms involve both metabolic and biochemical crosstalk pathways during the intimate interactions of PMN with other cell types at inflammatory sites. Here, we highlight several recent examples of how PMN coordinate the resolution of ongoing inflammation, with a particular focus on the gastrointestinal mucosa.

Original languageEnglish
Pages (from-to)75-82
Number of pages8
JournalImmunologic Research
Volume55
Issue number1-3
DOIs
Publication statusPublished - 01 Mar 2013
Externally publishedYes

Keywords

  • Colitis
  • Endothelium
  • Epithelium
  • Hypoxia-inducible factor
  • Inflammation
  • Metabolism
  • Mucosa
  • Murine model
  • Neutrophil
  • Nucleoside
  • Nucleotidase
  • Nucleotide

ASJC Scopus subject areas

  • Immunology

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