Using a murine model of Klebsiella pneumoniae bacterial infection, we demonstrate that gentamicin dissolving microarray patches, applied to murine ears, could control K. pneumoniae infection. Mice treated with microarray patches had reduced bacterial burden in the nasal associated lymphoid tissue and lungs, in comparison to their untreated counterparts. This proof of concept study represents the first published data on the in vivo delivery of the antibiotic gentamicin, via dissolving microarray patches resulting in control of bacterial infection.
Bibliographical noteCopyright © 2019 Rodgers et al.
- Klebsiella pneumoniae
- Transdermal delivery
ASJC Scopus subject areas
- Pharmacology (medical)
- Infectious Diseases
Exploring new regulators of innate immune signalling pathways with a particular focus on inflammasomesAuthor: Edwards, K., Jul 2020
Student thesis: Doctoral Thesis › Doctor of Philosophy