Abstract
Using a murine model of Klebsiella pneumoniae bacterial infection, we demonstrate that gentamicin dissolving microarray patches, applied to murine ears, could control K. pneumoniae infection. Mice treated with microarray patches had reduced bacterial burden in the nasal associated lymphoid tissue and lungs, in comparison to their untreated counterparts. This proof of concept study represents the first published data on the in vivo delivery of the antibiotic gentamicin, via dissolving microarray patches resulting in control of bacterial infection.
Original language | English |
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Pages (from-to) | e02612-e02618 |
Number of pages | 7 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 63 |
Issue number | 5 |
Early online date | 11 Mar 2019 |
DOIs | |
Publication status | Published - 01 May 2019 |
Bibliographical note
Copyright © 2019 Rodgers et al.Keywords
- Gentamicin
- Klebsiella pneumoniae
- Microarray
- Transdermal delivery
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases
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Dive into the research topics of 'Control of Klebsiella pneumoniae infection in mice using dissolving microarray patches containing gentamicin'. Together they form a unique fingerprint.Student theses
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Exploring new regulators of innate immune signalling pathways with a particular focus on inflammasomes
Edwards, K. (Author), Kissenpfennig, A. (Supervisor) & Moynagh, P. (Supervisor), Jul 2020Student thesis: Doctoral Thesis › Doctor of Philosophy
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