Control of Klebsiella pneumoniae infection in mice using dissolving microarray patches containing gentamicin

Aoife M Rodgers, Maelíosa T.C McCrudden, Aaron J Courtenay, Mary-Carmel Kearney, Katherine L Edwards, Rebecca J Ingram, Jose Bengoechea, Ryan F Donnelly*

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Citations (Scopus)
139 Downloads (Pure)

Abstract

Using a murine model of Klebsiella pneumoniae bacterial infection, we demonstrate that gentamicin dissolving microarray patches, applied to murine ears, could control K. pneumoniae infection. Mice treated with microarray patches had reduced bacterial burden in the nasal associated lymphoid tissue and lungs, in comparison to their untreated counterparts. This proof of concept study represents the first published data on the in vivo delivery of the antibiotic gentamicin, via dissolving microarray patches resulting in control of bacterial infection.

Original languageEnglish
Pages (from-to)e02612-e02618
Number of pages7
JournalAntimicrobial Agents and Chemotherapy
Volume63
Issue number5
Early online date11 Mar 2019
DOIs
Publication statusPublished - 01 May 2019

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Bibliographical note

Copyright © 2019 Rodgers et al.

Keywords

  • Gentamicin
  • Klebsiella pneumoniae
  • Microarray
  • Transdermal delivery

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