Controlled Drug Administration by a Fractional PID

Pantelis Sopasakis, Haralambos Sarimveis

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Amiodarone is an antiarrhythmic drug that exhibits highly complex and non-exponential dynamics whose controlled administration has important implications for its clinical use especially for long-term therapies. Its pharmacokinetics has been accurately modelled using a fractional-order compartmental model. In this paper we design a fractional-order PID controller and we evaluate its dynamical characteristics in terms of the stability margins of the closed loop and the ability of the controlled system to attenuate various sources of noise and uncertainty.
Original languageUndefined/Unknown
Pages (from-to)8421 - 8426
JournalIFAC Proceedings Volumes
Issue number3
Publication statusPublished - 2014

Bibliographical note

19th IFAC World Congress


  • Biomedical control, Biomedical systems, Pharmacokinetics and drug delivery, Control of physiological and clinical variables, Physiological model, Fractional control

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