Amiodarone is an antiarrhythmic drug that exhibits highly complex and non-exponential dynamics whose controlled administration has important implications for its clinical use especially for long-term therapies. Its pharmacokinetics has been accurately modelled using a fractional-order compartmental model. In this paper we design a fractional-order PID controller and we evaluate its dynamical characteristics in terms of the stability margins of the closed loop and the ability of the controlled system to attenuate various sources of noise and uncertainty.
Bibliographical note19th IFAC World Congress
- Biomedical control, Biomedical systems, Pharmacokinetics and drug delivery, Control of physiological and clinical variables, Physiological model, Fractional control