Controlled fragrance delivery in functionalised ionic liquid-enzyme systems

Marijana Blesic*, H. Q. Nimal Gunaratne, Peter Nockemann, Philip McCarron, Kenneth R. Seddon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)
291 Downloads (Pure)


It is often believed that both ionic liquids and surfactants generally behave as non-specific denaturants of proteins. In this paper, it is shown that amphiphilic ionic liquids bearing a long alkyl chain and a target molecule, where the target molecule is appended via a carboxylic ester functionality, can represent super-substrates that enable the catalytic activity of an enzyme, even at high concentrations in solution. Menthol has been chosen as the target molecule for slow and controlled fragrance delivery, and it was found that the rate of the menthol release can be controlled by the chemical structure of the ionic liquid. At a more fundamental level, this study offers an insight into the complex hydrophobic, electrostatic, and hydrogen bond interactions between the enzyme and substrate.

Original languageEnglish
Pages (from-to)329-333
JournalRSC Advances
Issue number2
Publication statusPublished - 08 Nov 2013


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