TY - JOUR
T1 - Controlled release and antioxidant activity of chitosan or its glucosamine water-soluble derivative microcapsules loaded with quercetin
AU - Braber, Noelia L. Vanden
AU - Paredes, Alejandro J.
AU - Rossi, Yanina E.
AU - Porporatto, Carina
AU - Allemandi, Daniel A.
AU - Borsarelli, Claudio D.
AU - Correa, Silvia G.
AU - Montenegro, Mariana A.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - The controlled release and antioxidant properties of the flavonoid quercetin (Qr) incorporated into crosslinked microcapsules using chitosan (Ch) or its derivative modified with glucosamine by Maillard reaction (GACh) as wall materials were evaluated. The microcapsules containing Qr (Qr-MC) were obtained by the spray-drying technique with high microencapsulation efficiency of Qr, and with spherical shape of average size of 2.0 ± 1.5 μm. Under gastrointestinal simulated conditions, the Qr-MC showed controlled release within few hours, being the release rate faster under gastric than intestinal conditions. The rate of release of Qr by GACh-MC was almost double than those made with Ch under gastric conditions, but the same release rate was observed for both Qr-MC under intestinal conditions. Efficient antioxidant activity of the Qr-MC against reactive oxygen species (ROS) including hydroxyl radical HO•, anion superoxide O2•− and singlet oxygen 1O2 was observed, indicating that Ch biopolymers are also suitable functional coating materials for flavonoid microencapsulation, regarding the gastro resistance, antioxidant activity and controlled release properties that could increase the bioavailability of the flavonoid.
AB - The controlled release and antioxidant properties of the flavonoid quercetin (Qr) incorporated into crosslinked microcapsules using chitosan (Ch) or its derivative modified with glucosamine by Maillard reaction (GACh) as wall materials were evaluated. The microcapsules containing Qr (Qr-MC) were obtained by the spray-drying technique with high microencapsulation efficiency of Qr, and with spherical shape of average size of 2.0 ± 1.5 μm. Under gastrointestinal simulated conditions, the Qr-MC showed controlled release within few hours, being the release rate faster under gastric than intestinal conditions. The rate of release of Qr by GACh-MC was almost double than those made with Ch under gastric conditions, but the same release rate was observed for both Qr-MC under intestinal conditions. Efficient antioxidant activity of the Qr-MC against reactive oxygen species (ROS) including hydroxyl radical HO•, anion superoxide O2•− and singlet oxygen 1O2 was observed, indicating that Ch biopolymers are also suitable functional coating materials for flavonoid microencapsulation, regarding the gastro resistance, antioxidant activity and controlled release properties that could increase the bioavailability of the flavonoid.
U2 - 10.1016/j.ijbiomac.2018.01.085
DO - 10.1016/j.ijbiomac.2018.01.085
M3 - Article
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
SN - 0141-8130
ER -