Controlled release of a model antibacterial drug from a novel self-lubricating silicone biomaterial

Karl Malcolm, David Woolfson, Sean Gorman, David Jones

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Abstract There is considerable interest in developing medical devices that provide controlled delivery of biologically active agents, for example, to reduce the incidence of device-related infection. Silicone elastomers are one of the commonest biomaterials used in medical device production. However, they have a relatively high coefficient of friction and the resulting lack of lubricity can cause pain and tissue damage on device insertion and removal. Novel silicone cross-linking agents have recently been reported that produce inherently ‘self-lubricating’ silicone elastomers with very low coefficients of friction. In this study, the model antibacterial drug metronidazole has been incorporated into these self-lubricating silicone elastomers to produce a novel bioactive biomaterial. The in vitro release characteristics of the bioactive component were evaluated as a function of cross-linker composition and drug loading. Although conventional matrix-type release kinetics were observed for metronidazole from the silicone systems, it was also observed that increasing the concentration of the cross-linking agent responsible for the lubricious character (tetra(oleyloxy)silane) relative to that of the standard non-lubricious cross-linking agent (tetrapropoxysilane) produced an increase in the metronidazole flux rate by up to 65% for a specified drug loading. The results highlight the potential for developing lubricious silicone medical devices with enhanced drug release characteristics.
Original languageEnglish
Pages (from-to)313-320
Number of pages8
JournalJournal of Controlled Release
Volume97(2)
Issue number2
DOIs
Publication statusPublished - 18 Jun 2004

ASJC Scopus subject areas

  • Pharmaceutical Science

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