Convenient synthesis of 5′-methyl-2′-desoxyuridines

S. N. Mikhailov*, N. Sh Padyukova, K. I. Panov

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A convenient method has been developed for the synthesis of 5′-methyl-2′-desoxyuridines. Chlorination of 5′-O-benzoyl-5′-methyluridines with a mixture of Ph3P and CCl4 in DMF affords the 2′-desoxy-2′-chloro-derivatives, which are then reduced with tributyltin hydride. The crystalline 5′-O-benzoyl-5′-methyl-2′-desoxyuridines were obtained in overall yields of 40-60%. In a similar way, 5′-O-benzoyluridine has given 5′-O-benzoyl-2′-desoxyuridine.

Original languageEnglish
Pages (from-to)203-205
Number of pages3
JournalChemistry of Heterocyclic Compounds
Issue number2
Publication statusPublished - Feb 1989
Externally publishedYes

Bibliographical note

Copyright 2007 Elsevier B.V., All rights reserved.

ASJC Scopus subject areas

  • Organic Chemistry


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