As many countries move towards fossil fuel divestment, greater emphasis is being placed on the use of sustainable sources for the production of fuels and chemicals. Due to the current scale of production of petroleum, a mixed portfolio of alternative sources is needed to supply these demands. Biomass is a potential renewable and sustainable source for the production of biofuels and valuable chemicals. The conversion of biomass into biofuels and bio-derived platform chemicals to be directly placed into chemical production streams has been intensely explored over the last decade. One interesting avenue highlighted in this chapter is the development of systems that combine bio- and chemo-catalysis to convert biomass into value-added chemicals: in this endeavour, the targeted transformations are enabled by the concerted action of both chemical and biological catalysts. The combination of racemization catalysts and bio-catalytic enzymes for the production of optically pure products such as alcohols, amines and acyloins, in dynamic kinetic resolution, is hereby discussed along with several recent examples of biomass valorisation using actual, or potential, protocols involving the simultaneous use of both bio- and chemo-catalytic steps.