COP and clathrin-coated vesicle budding: different pathways, common approaches

Harvey T McMahon, Ian G Mills

Research output: Contribution to journalArticlepeer-review

220 Citations (Scopus)


Vesicle and tubule transport containers move proteins and lipids from one membrane system to another. Newly forming transport containers frequently have electron-dense coats. Coats coordinate the accumulation of cargo and sculpt the membrane. Recent advances have shown that components of both COP1 and clathrin-adaptor coats share the same structure and the same motif-based cargo recognition and accessory factor recruitment mechanisms, which leads to insights on conserved aspects of coat recruitment, polymerisation and membrane deformation. These themes point to the way in which evolutionarily conserved features underpin these diverse pathways.

Original languageEnglish
Pages (from-to)379-91
Number of pages13
JournalCurrent opinion in cell biology
Issue number4
Publication statusPublished - Aug 2004


  • ADP-Ribosylation Factor 1
  • Adaptor Proteins, Vesicular Transport
  • Animals
  • Biological Transport
  • COP-Coated Vesicles
  • Clathrin
  • Clathrin-Coated Vesicles
  • Coat Protein Complex I
  • Coated Pits, Cell-Membrane
  • Endoplasmic Reticulum
  • Humans
  • Models, Biological
  • Protein Structure, Tertiary

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