Copper complexes with a flexible piperazinyl arm: nuclearity driven catecholase activity and interactions with biomolecules

Mriganka Das, Poulami Mandal, Novina Malviya, Indrani Choudhuri, Maria Adilia Januário Charmier, Susana Morgado, Shaikh M. Mobin, Biswarup Pathak, Suman Mukhopadhyay

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Three new Cu(II) complexes, [Cu(HL1)(pyridine)(H2O)](ClO4)2·2MeOH (1), [Cu2(HL1)2(NO3)2](NO3)2·3H2O (2) and [Cu(HL2)(NO3)2]·MeCN (3), have been synthesized from two Schiff base ligands [HL1 = 1-phenyl-3-((2-(piperazin-4-yl)ethyl)imino)but-1-en-1-ol and HL2 = 4-((2-(piperazin-1-yl)ethyl)imino)pent-2-en-2-ol] using the chair conformer of a flexible piperazinyl moiety. Structural analysis reveals that 1 and 3 are monomeric Cu(II) complexes consisting of five- and six-coordinate Cu(II), respectively, whereas 2 is a dinuclear Cu(II) complex consisting of two different Cu(II) centers, one square planar with the other distorted octahedral. Screening tests were conducted to quantify the binding of 1–3 towards DNA and BSA as well as the DNA cleavage activity of these complexes using gel electrophoresis. Enzyme kinetic studies were also performed for the complexes mimicking catecholase-like activities. Antibacterial activities of these complexes were also examined towards Methicillin-Resistant Staphylococcus aureus bacteria. The results reflect that 2 is more active than the monomeric complexes, which is further corroborated by density functional theory study.
Original languageEnglish
Pages (from-to)3619-3637
Number of pages19
JournalJournal of Coordination Chemistry
Volume69
Issue number24
Early online date26 Sep 2016
DOIs
Publication statusPublished - 16 Dec 2016
Externally publishedYes

Keywords

  • Cu(II) complexes with crystal structure
  • DNA binding
  • antimicrobial activity
  • catecholase like activity
  • cleavage and BSA binding
  • computational study

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