Correlation between Membrane Partitioning and Functional Activity in a Single Lipid Vesicle Assay Establishes Design Guidelines for Antiviral Peptides

Joshua  A. Jackman; Rathi   Saravanan; Yibang   Zhang; Seyed  R. Tabaei; Nam-Joon   Cho

doi:10.1002/smll.201403638

Correlation between Membrane Partitioning and Functional Activity in a Single Lipid Vesicle Assay Establishes Design Guidelines for Antiviral Peptides

Joshua A. Jackman, Rathi Saravanan, Yibang Zhang, Seyed R. Tabaei, Nam-Joon Cho

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

The nanometer-scale discrimination of virus-rupturing peptides is tested using lipid membrane platforms. In combination with single-vesicle analysis of peptide-induced vesicle rupture, a correlation between membrane partitioning and biologically relevant activities is established. Taken together, the findings support that the degree of rupture activity should be balanced by membrane curvature-selectivity for optimal therapeutic properties of antiviral peptides.

Original language	English
Pages (from-to)	2372-2379
Journal	Small
Volume	11
Issue number	20
Early online date	23 Jan 2015
DOIs	https://doi.org/10.1002/smll.201403638
Publication status	Published - 27 May 2015
Externally published	Yes

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title = "Correlation between Membrane Partitioning and Functional Activity in a Single Lipid Vesicle Assay Establishes Design Guidelines for Antiviral Peptides",

abstract = "The nanometer-scale discrimination of virus-rupturing peptides is tested using lipid membrane platforms. In combination with single-vesicle analysis of peptide-induced vesicle rupture, a correlation between membrane partitioning and biologically relevant activities is established. Taken together, the findings support that the degree of rupture activity should be balanced by membrane curvature-selectivity for optimal therapeutic properties of antiviral peptides.",

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AU - Tabaei, Seyed R.

AU - Cho, Nam-Joon

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AB - The nanometer-scale discrimination of virus-rupturing peptides is tested using lipid membrane platforms. In combination with single-vesicle analysis of peptide-induced vesicle rupture, a correlation between membrane partitioning and biologically relevant activities is established. Taken together, the findings support that the degree of rupture activity should be balanced by membrane curvature-selectivity for optimal therapeutic properties of antiviral peptides.

U2 - 10.1002/smll.201403638

DO - 10.1002/smll.201403638

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ER -

Correlation between Membrane Partitioning and Functional Activity in a Single Lipid Vesicle Assay Establishes Design Guidelines for Antiviral Peptides

Abstract

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