Correlation between Retinal Vessel Calibre and Neurodegeneration in Patients with Type 2 Diabetes Mellitus in the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR)

Ulrik Frydkjaer-Olsen, Rasmus Soegaard Hansen, Rafael Simó, José Cunha-Vaz, Tunde Peto, Jakob Grauslund, EUROCONDOR

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Abstract

PURPOSE: To investigate the correlation between retinal vessel calibre and measurements of neurodegeneration in patients with type 2 diabetes (T2D) and no or early diabetic retinopathy (DR).

METHODS: Baseline data on 440 patients with T2D from the EUROCONDOR clinical trial were used. DR was graded according to the Early Treatment of Diabetic Retinopathy Study (ETDRS) scale, and patients with ETDRS levels 10-35 were included. Retinal vessel diameters were measured by semi-automatic software. Calibres were summarized into central retinal artery and vein equivalents (CRAE and CRVE).

RESULTS: Median age and diabetes duration were 64.0 and 10.3 years, respectively. ETDRS levels were 10 (42.3%), 20 (27.5%) and 35 (30.2%). The median CRAE and CRVE were 146.7 and 215.3 µm, respectively. CRAE did not differ according to ETRDS level (p = 0.12), but wider CRVE were found in patients with higher ETDRS levels (p = 0.04). In a multivariable linear regression model, CRAE was associated with macular ganglion cell layer thickness (coefficient 0.27 per micrometre, p < 0.01), and CRVE was correlated with macular retinal thickness (coefficient -0.07 per micrometre, p = 0.04) and retinal nerve fibre layer thickness at the optic disc (coefficient 0.32 per micrometre, p < 0.01).

CONCLUSION: Retinal vessel calibre was independently associated with structural changes of the neuroretina in patients with no or early DR.

Original languageEnglish
Pages (from-to)10-6
Number of pages7
JournalOphthalmic Research
Volume56
Issue number1
DOIs
Publication statusPublished - 08 Apr 2016

Keywords

  • Adrenergic alpha-2 Receptor Agonists
  • Aged
  • Brimonidine Tartrate
  • Diabetes Mellitus, Type 2
  • Diabetic Retinopathy
  • Drug Therapy, Combination
  • Electroretinography
  • Female
  • Follow-Up Studies
  • Hormones
  • Humans
  • Jupiter
  • Male
  • Middle Aged
  • Neuroprotective Agents
  • Ophthalmic Solutions
  • Prospective Studies
  • Retinal Degeneration
  • Retinal Ganglion Cells
  • Retinal Vessels
  • Somatostatin
  • Time Factors
  • Tomography, Optical Coherence
  • Treatment Outcome
  • Clinical Trial, Phase II
  • Clinical Trial, Phase III
  • Journal Article
  • Multicenter Study
  • Randomized Controlled Trial

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