Covalent organic framework membrane for size selective release of small molecules and peptide: In vitro

Hamideh Rezvani Alanagh, Iman Rostami, Mohammad Taleb, Xiaoqing Gao, Yadong Zhang, Abdul Muqsit Khattak, Xiao He, Lianshan Li, Zhiyong Tang

Research output: Contribution to journalArticlepeer-review

Abstract

The ability to control small drug release is crucial in biomedicine, especially for inhibiting the side effects of drugs, but it is still challenging. Herein, to mimic the controlled release of drugs, the release of organic molecules, e.g., small organic dyes and peptides, through Covalent Organic Framework (COF) membranes with ordered nanoscale pores has been investigated, showing constant zero-order release behaviours. Meanwhile, biological assessments show the good biocompatibility of the COF membrane-based release system, and the high stability of the COF membrane was manifested by the long-term release of small molecules in aqueous media.
Original languageEnglish
Pages (from-to)7899-7903
Number of pages5
JournalJournal of Materials Chemistry B
Volume8
Issue number35
Early online date13 Aug 2020
DOIs
Publication statusPublished - 21 Sep 2020
Externally publishedYes

Fingerprint

Dive into the research topics of 'Covalent organic framework membrane for size selective release of small molecules and peptide: In vitro'. Together they form a unique fingerprint.

Cite this