TY - JOUR
T1 - Covalent organic framework membrane for size selective release of small molecules and peptide: In vitro
AU - Rezvani Alanagh, Hamideh
AU - Rostami, Iman
AU - Taleb, Mohammad
AU - Gao, Xiaoqing
AU - Zhang, Yadong
AU - Khattak, Abdul Muqsit
AU - He, Xiao
AU - Li, Lianshan
AU - Tang, Zhiyong
PY - 2020/9/21
Y1 - 2020/9/21
N2 - The ability to control small drug release is crucial in biomedicine, especially for inhibiting the side effects of drugs, but it is still challenging. Herein, to mimic the controlled release of drugs, the release of organic molecules, e.g., small organic dyes and peptides, through Covalent Organic Framework (COF) membranes with ordered nanoscale pores has been investigated, showing constant zero-order release behaviours. Meanwhile, biological assessments show the good biocompatibility of the COF membrane-based release system, and the high stability of the COF membrane was manifested by the long-term release of small molecules in aqueous media.
AB - The ability to control small drug release is crucial in biomedicine, especially for inhibiting the side effects of drugs, but it is still challenging. Herein, to mimic the controlled release of drugs, the release of organic molecules, e.g., small organic dyes and peptides, through Covalent Organic Framework (COF) membranes with ordered nanoscale pores has been investigated, showing constant zero-order release behaviours. Meanwhile, biological assessments show the good biocompatibility of the COF membrane-based release system, and the high stability of the COF membrane was manifested by the long-term release of small molecules in aqueous media.
U2 - 10.1039/d0tb01416h
DO - 10.1039/d0tb01416h
M3 - Article
C2 - 32845948
VL - 8
SP - 7899
EP - 7903
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
SN - 2050-750X
IS - 35
ER -