Criteria required for an acceptable point-of-care test for UTI detection: Obtaining consensus using the Delphi technique

Nichola-Jane M. Weir, Sally H. Pattison, Paddy Kearney, Bob Stafford, Gerard J. Gormley, Martin A. Crockard, Deirdre F. Gilpin, Michael M. Tunney, Carmel M. Hughes

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)
215 Downloads (Pure)

Abstract

Background
Urinary Tract Infections (UTIs) are common bacterial infections, second only to respiratory tract infections and particularly prevalent within primary care. Conventional detection of UTIs is culture, however, return of results can take between 24 and 72 hours. The introduction of a point of care (POC) test would allow for more timely identification of UTIs, facilitating improved, targeted treatment. This study aimed to obtain consensus on the criteria required for a POC UTI test, to meet patient need within primary care.

Methods
Criteria for consideration were compiled by the research team. These criteria were validated through a two-round Delphi process, utilising an expert panel of healthcare professionals from across Europe and United States of America. Using web-based questionnaires, panellists recorded their level of agreement with each criterion based on a 5-point Likert Scale, with space for comments. Using median response, interquartile range and comments provided, criteria were accepted/rejected/revised depending on pre-agreed cut-off scores.

Results
The first round questionnaire presented thirty-three criteria to the panel, of which 22 were accepted. Consensus was not achieved for the remaining 11 criteria. Following response review, one criterion was removed, while after revision, the remaining 10 criteria entered the second round. Of these, four were subsequently accepted, resulting in 26 criteria considered appropriate for a POC test to detect urinary infections.

Conclusion
This study generated an approved set of criteria for a POC test to detect urinary infections. Criteria acceptance and comments provided by the healthcare professionals also supports the development of a multiplex point of care UTI test.
Original languageEnglish
Article numbere0198595
Number of pages13
JournalPLoS ONE
Volume13
Issue number6
DOIs
Publication statusPublished - 07 Jun 2018

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