Critical care ATLAS CLOVERS

Kelsey D. Sack*, Chandrashish Chakravarty, Juliana Carvalho Ferreira, Daniela Helena Machado Freitas, Chris McGrath, Mark E. Mikkelsen, Matteo Di Nardo, Elisabeth Riviello, Michael Root, Jon A. Silversides, Theogene Twagirumugabe, Doris Uwamahoro

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Downloads (Pure)


The practice of critical care is dependent not only on the particular patient population served but also the context in which critical care is provided, including culture and regional norms and resources. How clinicians interpret and implement new evidence or guideline recommendations is affected by their unique context. In 2023, the CLOVERS trial was published. The CLOVERS trial was a trial of 1563 patients which studied early vasopressor initiation versus liberal fluid initiation after an initial fluid bolus for patients presenting in the United States with septic shock. No mortality difference was found between the two treatment arms. In this article, adult and pediatric critical care clinicians from USA, UK, Italy, Rwanda, India, and Brazil describe how CLOVERS has impacted or will impact their practice.

Original languageEnglish
Article number100043
Number of pages8
JournalCHEST Critical Care
Issue number1
Early online date23 Dec 2023
Publication statusPublished - Mar 2024


Dive into the research topics of 'Critical care ATLAS CLOVERS'. Together they form a unique fingerprint.

Cite this