Current and future trends in biomarker discovery and development of companion diagnostics for arthritis

David S. Gibson*, Michael J. Bustard, Cathy M. Mcgeough, Helena A. Murray, Martin A. Crockard, Andrew Mcdowell, Jayne K. Blayney, Philip V. Gardiner, Anthony J. Bjourson

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)

Abstract

Musculoskeletal diseases such as rheumatoid arthritis are complex multifactorial disorders that are chronic in nature and debilitating for patients. A number of drug families are available to clinicians to manage these disorders but few tests exist to target these to the most responsive patients. As a consequence, drug failure and switching to drugs with alternate modes of action is common. In parallel, a limited number of laboratory tests are available which measure biological indicators or 'biomarkers' of disease activity, autoimmune status, or joint damage. There is a growing awareness that assimilating the fields of drug selection and diagnostic tests into 'companion diagnostics' could greatly advance disease management and improve outcomes for patients. This review aims to highlight: the current applications of biomarkers in rheumatology with particular focus on companion diagnostics; developments in the fields of proteomics, genomics, microbiomics, imaging and bioinformatics and how integration of these technologies into clinical practice could support therapeutic decisions.

Original languageEnglish
Pages (from-to)219-234
JournalExpert review of molecular diagnostics
Volume15
Issue number2
DOIs
Publication statusPublished - 01 Feb 2015
Externally publishedYes

Keywords

  • bioinformatics
  • companion diagnostics
  • genomics
  • imaging
  • microbiomics
  • proteomics
  • rheumatology, stratified medicine

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

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