Current and future trends in biomarker discovery and development of companion diagnostics for arthritis

David S. Gibson; Michael J. Bustard; Cathy M. Mcgeough; Helena A. Murray; Martin A. Crockard; Andrew Mcdowell; Jayne K. Blayney; Philip V. Gardiner; Anthony J. Bjourson

doi:10.1586/14737159.2015.969244

Current and future trends in biomarker discovery and development of companion diagnostics for arthritis

David S. Gibson^*, Michael J. Bustard, Cathy M. Mcgeough, Helena A. Murray, Martin A. Crockard, Andrew Mcdowell, Jayne K. Blayney, Philip V. Gardiner, Anthony J. Bjourson

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

Abstract

Musculoskeletal diseases such as rheumatoid arthritis are complex multifactorial disorders that are chronic in nature and debilitating for patients. A number of drug families are available to clinicians to manage these disorders but few tests exist to target these to the most responsive patients. As a consequence, drug failure and switching to drugs with alternate modes of action is common. In parallel, a limited number of laboratory tests are available which measure biological indicators or 'biomarkers' of disease activity, autoimmune status, or joint damage. There is a growing awareness that assimilating the fields of drug selection and diagnostic tests into 'companion diagnostics' could greatly advance disease management and improve outcomes for patients. This review aims to highlight: the current applications of biomarkers in rheumatology with particular focus on companion diagnostics; developments in the fields of proteomics, genomics, microbiomics, imaging and bioinformatics and how integration of these technologies into clinical practice could support therapeutic decisions.

Original language	English
Pages (from-to)	219-234
Journal	Expert review of molecular diagnostics
Volume	15
Issue number	2
DOIs	https://doi.org/10.1586/14737159.2015.969244
Publication status	Published - 01 Feb 2015
Externally published	Yes

Keywords

bioinformatics
companion diagnostics
genomics
imaging
microbiomics
proteomics
rheumatology, stratified medicine

ASJC Scopus subject areas

Pathology and Forensic Medicine
Molecular Medicine
Molecular Biology
Genetics

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Gibson, David S. ; Bustard, Michael J. ; Mcgeough, Cathy M. ; Murray, Helena A. ; Crockard, Martin A. ; Mcdowell, Andrew ; Blayney, Jayne K. ; Gardiner, Philip V. ; Bjourson, Anthony J. / Current and future trends in biomarker discovery and development of companion diagnostics for arthritis. In: Expert review of molecular diagnostics. 2015 ; Vol. 15, No. 2. pp. 219-234.

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abstract = "Musculoskeletal diseases such as rheumatoid arthritis are complex multifactorial disorders that are chronic in nature and debilitating for patients. A number of drug families are available to clinicians to manage these disorders but few tests exist to target these to the most responsive patients. As a consequence, drug failure and switching to drugs with alternate modes of action is common. In parallel, a limited number of laboratory tests are available which measure biological indicators or 'biomarkers' of disease activity, autoimmune status, or joint damage. There is a growing awareness that assimilating the fields of drug selection and diagnostic tests into 'companion diagnostics' could greatly advance disease management and improve outcomes for patients. This review aims to highlight: the current applications of biomarkers in rheumatology with particular focus on companion diagnostics; developments in the fields of proteomics, genomics, microbiomics, imaging and bioinformatics and how integration of these technologies into clinical practice could support therapeutic decisions.",

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Current and future trends in biomarker discovery and development of companion diagnostics for arthritis. / Gibson, David S.; Bustard, Michael J.; Mcgeough, Cathy M.; Murray, Helena A.; Crockard, Martin A.; Mcdowell, Andrew ; Blayney, Jayne K.; Gardiner, Philip V.; Bjourson, Anthony J.

In: Expert review of molecular diagnostics, Vol. 15, No. 2, 01.02.2015, p. 219-234.

Research output: Contribution to journal › Review article › peer-review

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