Cutting edge: Langerin+ dendritic cells in the mesenteric lymph node set the stage for skin and gut immune system cross-talk.

S.Y. Chang, H.R. Cha, O. Igarashi, P.D. Rennert, Adrien Kissenpfennig, B. Malissen, M. Nanno, H. Kiyono, M.N. Kweon

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

Topical transcutaneous immunization (TCI) presents many clinical advantages, but its underlying mechanism remains unknown. TCI induced Ag-specific IgA Ab-secreting cells expressing CCR9 and CCR10 in the small intestine in a retinoic acid-dependent manner. These intestinal IgA Abs were maintained in Peyer\'s patch-null mice but abolished in the Peyer\'s patch- and lymph node-null mice. The mesenteric lymph node (MLN) was shown to be the site of IgA isotype class switching after TCI. Unexpectedly, langerin(+)CD8alpha(-) dendritic cells emerged in the MLN after TCI; they did not migrate from the skin but rather differentiated rapidly from bone marrow precursors. Depletion of langerin(+) cells impaired intestinal IgA Ab responses after TCI. Taken together, these findings suggest that MLN is indispensable for the induction of intestinal IgA Abs following skin immunization and that cross-talk between the skin and gut immune systems might be mediated by langerin(+) dendritic cells in the MLN.
Original languageEnglish
Pages (from-to)4361-4365
Number of pages5
JournalJournal of Immunology
Volume180(7)
Issue number7
Publication statusPublished - 01 Apr 2008

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Cutting edge: Langerin+ dendritic cells in the mesenteric lymph node set the stage for skin and gut immune system cross-talk.'. Together they form a unique fingerprint.

Cite this