Cyclooxygenase-2 expression correlates with phaeochromocytoma malignancy.

I.S. Cadden, A.B. Atkinson, B. Johnston, K. Pogue, R. Connolly, D. McCance, J.E.S. Ardill, C.F. Russell, Ann McGinty

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13 Citations (Scopus)

Abstract

Abstract Aims: Phaeochromocytomas are rare but potentially life-threatening neuroendocrine tumours of the adrenal medulla or sympathetic nervous system ganglia. There are no histological features which reliably differentiate benign from malignant phaeochromocytomas. The current study evaluated cyclooxygenase-2 (Cox-2) and Bcl-2 as tissue-based biomarkers of phaeochromocytoma prognosis. Methods and Results: Cox-2 and Bcl-2 expression were examined immunohistochemically in tissue from forty-one sporadic phaeochromocytoma patients followed up for a minimum of five years after diagnosis. There was a statistically significant association between Cox-2 histoscore (intensity x porportion) and the development of tumour recurrence or metastases (p=0.006). A significant relationship between the co-expression of Cox-2 and Bcl-2 in the primary tumour and the presence of recurrent disease was observed (p=0.034). A highly significant association was observed between, (i) the tumour-associated expression of these two oncoproteins (p=0.001) and, (ii) Cox-2 histoscore and the presence of Bcl-2 expression (p=0.002). Cox regression analysis demonstrated no significant relationship between, (i) the presence or absence of either Cox-2 or Bcl-2 and patient survival or, (ii) between Cox-2 histoscore and patient survival. Conclusions: These results suggest that Cox-2 and Bcl-2 may promote phaeochromocytoma malignancy and that these oncoproteins may be valuable surrogate markers of an aggressive tumour phenotype.
Original languageEnglish
Pages (from-to)00-00
Number of pages1
JournalHistopathology
Volume00
Issue number6
Publication statusPublished - Dec 2007

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Cell Biology

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    Cadden, I. S., Atkinson, A. B., Johnston, B., Pogue, K., Connolly, R., McCance, D., Ardill, J. E. S., Russell, C. F., & McGinty, A. (2007). Cyclooxygenase-2 expression correlates with phaeochromocytoma malignancy. Histopathology, 00(6), 00-00.