Cystic fibrosis pathogens survive for extended periods within cough-generated droplet nuclei

Michelle E Wood; Rebecca E Stockwell; Graham R Johnson; Kay A Ramsay; Laura J Sherrard; Timothy J Kidd; Joyce Cheney; Emma L Ballard; Peter O'Rourke; Nassib Jabbour; Claire E Wainwright; Luke D Knibbs; Peter D Sly; Lidia Morawska; Scott C Bell

doi:10.1136/thoraxjnl-2018-211567

Cystic fibrosis pathogens survive for extended periods within cough-generated droplet nuclei

Michelle E Wood, Rebecca E Stockwell, Graham R Johnson, Kay A Ramsay, Laura J Sherrard, Timothy J Kidd, Joyce Cheney, Emma L Ballard, Peter O'Rourke, Nassib Jabbour, Claire E Wainwright, Luke D Knibbs, Peter D Sly, Lidia Morawska, Scott C Bell

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Abstract

The airborne route is a potential pathway in the person-to-person transmission of bacterial strains among cystic fibrosis (CF) populations. In this cross-sectional study, we investigate the physical properties and survival of common non-Pseudomonas aeruginosa CF pathogens generated during coughing. We conclude that Gram-negative bacteria and Staphylococcus aureus are aerosolised during coughing, can travel up to 4 m and remain viable within droplet nuclei for up to 45 min. These results suggest that airborne person-to-person transmission is plausible for the CF pathogens we measured.

Original language	English
Journal	Thorax
Early online date	07 Apr 2018
DOIs	https://doi.org/10.1136/thoraxjnl-2018-211567
Publication status	Early online date - 07 Apr 2018

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Journal Article

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Cystic fibrosis pathogens survive for extended periods within cough-generated droplet nuclei
© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.This work is made available online in accordance with the publisher’s policies. Please refer to any applicable terms of use of the publisher.
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Laura Sherrard
- L.Sherrardqub.acuk
- School of Pharmacy - Lecturer
- Material and Advanced Technologies for Healthcare
Person: Academic

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Wood, M. E., Stockwell, R. E., Johnson, G. R., Ramsay, K. A., Sherrard, L. J., Kidd, T. J., Cheney, J., Ballard, E. L., O'Rourke, P., Jabbour, N., Wainwright, C. E., Knibbs, L. D., Sly, P. D., Morawska, L., & Bell, S. C. (2018). Cystic fibrosis pathogens survive for extended periods within cough-generated droplet nuclei. Thorax. https://doi.org/10.1136/thoraxjnl-2018-211567

Wood, Michelle E ; Stockwell, Rebecca E ; Johnson, Graham R ; Ramsay, Kay A ; Sherrard, Laura J ; Kidd, Timothy J ; Cheney, Joyce ; Ballard, Emma L ; O'Rourke, Peter ; Jabbour, Nassib ; Wainwright, Claire E ; Knibbs, Luke D ; Sly, Peter D ; Morawska, Lidia ; Bell, Scott C. / Cystic fibrosis pathogens survive for extended periods within cough-generated droplet nuclei. In: Thorax. 2018.

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abstract = "The airborne route is a potential pathway in the person-to-person transmission of bacterial strains among cystic fibrosis (CF) populations. In this cross-sectional study, we investigate the physical properties and survival of common non-Pseudomonas aeruginosa CF pathogens generated during coughing. We conclude that Gram-negative bacteria and Staphylococcus aureus are aerosolised during coughing, can travel up to 4 m and remain viable within droplet nuclei for up to 45 min. These results suggest that airborne person-to-person transmission is plausible for the CF pathogens we measured.",

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author = "Wood, {Michelle E} and Stockwell, {Rebecca E} and Johnson, {Graham R} and Ramsay, {Kay A} and Sherrard, {Laura J} and Kidd, {Timothy J} and Joyce Cheney and Ballard, {Emma L} and Peter O'Rourke and Nassib Jabbour and Wainwright, {Claire E} and Knibbs, {Luke D} and Sly, {Peter D} and Lidia Morawska and Bell, {Scott C}",

note = "{\textcopyright} Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.",

year = "2018",

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day = "7",

doi = "10.1136/thoraxjnl-2018-211567",

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Cystic fibrosis pathogens survive for extended periods within cough-generated droplet nuclei. / Wood, Michelle E; Stockwell, Rebecca E; Johnson, Graham R; Ramsay, Kay A; Sherrard, Laura J; Kidd, Timothy J; Cheney, Joyce; Ballard, Emma L; O'Rourke, Peter; Jabbour, Nassib; Wainwright, Claire E; Knibbs, Luke D; Sly, Peter D; Morawska, Lidia; Bell, Scott C.

In: Thorax, 07.04.2018.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Cystic fibrosis pathogens survive for extended periods within cough-generated droplet nuclei

AU - Wood, Michelle E

AU - Stockwell, Rebecca E

AU - Johnson, Graham R

AU - Ramsay, Kay A

AU - Sherrard, Laura J

AU - Kidd, Timothy J

AU - Cheney, Joyce

AU - Ballard, Emma L

AU - O'Rourke, Peter

AU - Jabbour, Nassib

AU - Wainwright, Claire E

AU - Knibbs, Luke D

AU - Sly, Peter D

AU - Morawska, Lidia

AU - Bell, Scott C

PY - 2018/4/7

Y1 - 2018/4/7

N2 - The airborne route is a potential pathway in the person-to-person transmission of bacterial strains among cystic fibrosis (CF) populations. In this cross-sectional study, we investigate the physical properties and survival of common non-Pseudomonas aeruginosa CF pathogens generated during coughing. We conclude that Gram-negative bacteria and Staphylococcus aureus are aerosolised during coughing, can travel up to 4 m and remain viable within droplet nuclei for up to 45 min. These results suggest that airborne person-to-person transmission is plausible for the CF pathogens we measured.

AB - The airborne route is a potential pathway in the person-to-person transmission of bacterial strains among cystic fibrosis (CF) populations. In this cross-sectional study, we investigate the physical properties and survival of common non-Pseudomonas aeruginosa CF pathogens generated during coughing. We conclude that Gram-negative bacteria and Staphylococcus aureus are aerosolised during coughing, can travel up to 4 m and remain viable within droplet nuclei for up to 45 min. These results suggest that airborne person-to-person transmission is plausible for the CF pathogens we measured.

KW - Journal Article

U2 - 10.1136/thoraxjnl-2018-211567

DO - 10.1136/thoraxjnl-2018-211567

M3 - Article

C2 - 29627800

JO - Thorax

JF - Thorax

SN - 0040-6376

ER -

Cystic fibrosis pathogens survive for extended periods within cough-generated droplet nuclei

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Laura Sherrard

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