Cystic fibrosis pathogens survive for extended periods within cough-generated droplet nuclei

Michelle E Wood; Rebecca E Stockwell; Graham R Johnson; Kay A Ramsay; Laura J Sherrard; Timothy J Kidd; Joyce Cheney; Emma L Ballard; Peter O'Rourke; Nassib Jabbour; Claire E Wainwright; Luke D Knibbs; Peter D Sly; Lidia Morawska; Scott C Bell

doi:10.1136/thoraxjnl-2018-211567

Cystic fibrosis pathogens survive for extended periods within cough-generated droplet nuclei

Michelle E Wood, Rebecca E Stockwell, Graham R Johnson, Kay A Ramsay, Laura J Sherrard, Timothy J Kidd, Joyce Cheney, Emma L Ballard, Peter O'Rourke, Nassib Jabbour, Claire E Wainwright, Luke D Knibbs, Peter D Sly, Lidia Morawska, Scott C Bell

School of Pharmacy

Research output: Contribution to journal › Article

10 Citations (Scopus)

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Abstract

The airborne route is a potential pathway in the person-to-person transmission of bacterial strains among cystic fibrosis (CF) populations. In this cross-sectional study, we investigate the physical properties and survival of common non-Pseudomonas aeruginosa CF pathogens generated during coughing. We conclude that Gram-negative bacteria and Staphylococcus aureus are aerosolised during coughing, can travel up to 4 m and remain viable within droplet nuclei for up to 45 min. These results suggest that airborne person-to-person transmission is plausible for the CF pathogens we measured.

Original language	English
Journal	Thorax
Early online date	07 Apr 2018
DOIs	https://doi.org/10.1136/thoraxjnl-2018-211567
Publication status	Early online date - 07 Apr 2018

Keywords

Journal Article

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Cystic fibrosis pathogens survive for extended periods within cough-generated droplet nuclei
© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.This work is made available online in accordance with the publisher’s policies. Please refer to any applicable terms of use of the publisher.
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Wood, M. E., Stockwell, R. E., Johnson, G. R., Ramsay, K. A., Sherrard, L. J., Kidd, T. J., Cheney, J., Ballard, E. L., O'Rourke, P., Jabbour, N., Wainwright, C. E., Knibbs, L. D., Sly, P. D., Morawska, L., & Bell, S. C. (2018). Cystic fibrosis pathogens survive for extended periods within cough-generated droplet nuclei. Thorax. https://doi.org/10.1136/thoraxjnl-2018-211567

Wood, Michelle E ; Stockwell, Rebecca E ; Johnson, Graham R ; Ramsay, Kay A ; Sherrard, Laura J ; Kidd, Timothy J ; Cheney, Joyce ; Ballard, Emma L ; O'Rourke, Peter ; Jabbour, Nassib ; Wainwright, Claire E ; Knibbs, Luke D ; Sly, Peter D ; Morawska, Lidia ; Bell, Scott C. / Cystic fibrosis pathogens survive for extended periods within cough-generated droplet nuclei. In: Thorax. 2018.

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abstract = "The airborne route is a potential pathway in the person-to-person transmission of bacterial strains among cystic fibrosis (CF) populations. In this cross-sectional study, we investigate the physical properties and survival of common non-Pseudomonas aeruginosa CF pathogens generated during coughing. We conclude that Gram-negative bacteria and Staphylococcus aureus are aerosolised during coughing, can travel up to 4 m and remain viable within droplet nuclei for up to 45 min. These results suggest that airborne person-to-person transmission is plausible for the CF pathogens we measured.",

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Cystic fibrosis pathogens survive for extended periods within cough-generated droplet nuclei. / Wood, Michelle E; Stockwell, Rebecca E; Johnson, Graham R; Ramsay, Kay A; Sherrard, Laura J; Kidd, Timothy J; Cheney, Joyce; Ballard, Emma L; O'Rourke, Peter; Jabbour, Nassib; Wainwright, Claire E; Knibbs, Luke D; Sly, Peter D; Morawska, Lidia; Bell, Scott C.

In: Thorax, 07.04.2018.

Research output: Contribution to journal › Article

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AU - Stockwell, Rebecca E

AU - Johnson, Graham R

AU - Ramsay, Kay A

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AU - Kidd, Timothy J

AU - Cheney, Joyce

AU - Ballard, Emma L

AU - O'Rourke, Peter

AU - Jabbour, Nassib

AU - Wainwright, Claire E

AU - Knibbs, Luke D

AU - Sly, Peter D

AU - Morawska, Lidia

AU - Bell, Scott C

PY - 2018/4/7

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N2 - The airborne route is a potential pathway in the person-to-person transmission of bacterial strains among cystic fibrosis (CF) populations. In this cross-sectional study, we investigate the physical properties and survival of common non-Pseudomonas aeruginosa CF pathogens generated during coughing. We conclude that Gram-negative bacteria and Staphylococcus aureus are aerosolised during coughing, can travel up to 4 m and remain viable within droplet nuclei for up to 45 min. These results suggest that airborne person-to-person transmission is plausible for the CF pathogens we measured.

AB - The airborne route is a potential pathway in the person-to-person transmission of bacterial strains among cystic fibrosis (CF) populations. In this cross-sectional study, we investigate the physical properties and survival of common non-Pseudomonas aeruginosa CF pathogens generated during coughing. We conclude that Gram-negative bacteria and Staphylococcus aureus are aerosolised during coughing, can travel up to 4 m and remain viable within droplet nuclei for up to 45 min. These results suggest that airborne person-to-person transmission is plausible for the CF pathogens we measured.

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