Cytokine gene polymorphisms in ischaemic heart disease: Investigation using family based tests of association

P.G. McGlinchey, M.S. Spence, Christopher Patterson, A.R. Allen, G. Murphy, David Savage, Alexander Maxwell, Pascal McKeown

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5 Citations (Scopus)


Atherosclerosis has an inflammatory basis, with cytokines, cellular adhesion molecules and pro-inflammatory cells having important roles in the initiation and progression of this process. Interleukin (IL) 6, IL-10 and transforming growth factor (TGF) β have been proposed as important modulators of the atherosclerotic process, with IL-6 having a pro-inflammatory, atherogenic effect and IL-10 and TGF-β having anti-inflammatory, protective roles. The possible role of functional polymorphisms in the promoter regions of the IL-6, IL-10 and TGF-β genes in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population using two recently described family-based tests of association. We genotyped 1,012 individuals from 386 families with at least one member prematurely affected with IHD. Using the combined transmission disequilibrium test (TDT)/sib-TDT and the pedigree disequilibrium test, no association between any of the IL-6 -174G/C, IL-10 -1082G/A and TGF-β -509C/T polymorphisms and IHD was found. Our data demonstrate that, in an Irish population, these polymorphisms are not associated with IHD. © Springer-Verlag 2004.
Original languageEnglish
Pages (from-to)756-761
Number of pages6
JournalJournal of Molecular Medicine
Issue number11
Publication statusPublished - 01 Nov 2004

ASJC Scopus subject areas

  • Medicine(all)


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