Cytokine phenotype, genotype, and renal outcomes at cardiac surgery

William T McBride, Penugonda S Prasad, Marilyn Armstrong, Christopher Patterson, Helen Gilliland, Andrew Drain, Alain Vuylsteke, Ray Latimer, Nadia Khalil, Alun Evans, François Cambien, Ian Young

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Cardiac surgery modulates pro- and anti-inflammatory cytokine balance involving plasma tumour necrosis factor alpha (TNFa) and interleukin-10 (IL-10) together with urinary transforming growth factor beta-1 (TGFß1), interleukin-1 receptor antagonist (IL1ra) and tumour necrosis factor soluble receptor-2 (TNFsr2). Effects on post-operative renal function are unclear. We investigated if following cardiac surgery there is a relationship between cytokine (a) phenotype and renal outcome; (b) genotype and phenotype and (c) genotype and renal outcome. Since angiotensin-2 (AG2), modulates TGFß1 production, we determined whether angiotensin converting enzyme insertion/deletion (ACE I/D) genotype affects urinary TGFß1 phenotype as well as renal outcome.
Original languageEnglish
Pages (from-to)275-84
Number of pages10
JournalCytokine
Volume61
Issue number1
DOIs
Publication statusPublished - 2013

Fingerprint Dive into the research topics of 'Cytokine phenotype, genotype, and renal outcomes at cardiac surgery'. Together they form a unique fingerprint.

  • Cite this

    McBride, W. T., Prasad, P. S., Armstrong, M., Patterson, C., Gilliland, H., Drain, A., Vuylsteke, A., Latimer, R., Khalil, N., Evans, A., Cambien, F., & Young, I. (2013). Cytokine phenotype, genotype, and renal outcomes at cardiac surgery. Cytokine, 61(1), 275-84. https://doi.org/10.1016/j.cyto.2012.10.008