Cytokine phenotype, genotype, and renal outcomes at cardiac surgery

William T McBride, Penugonda S Prasad, Marilyn Armstrong, Christopher Patterson, Helen Gilliland, Andrew Drain, Alain Vuylsteke, Ray Latimer, Nadia Khalil, Alun Evans, François Cambien, Ian Young

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Cardiac surgery modulates pro- and anti-inflammatory cytokine balance involving plasma tumour necrosis factor alpha (TNFa) and interleukin-10 (IL-10) together with urinary transforming growth factor beta-1 (TGFß1), interleukin-1 receptor antagonist (IL1ra) and tumour necrosis factor soluble receptor-2 (TNFsr2). Effects on post-operative renal function are unclear. We investigated if following cardiac surgery there is a relationship between cytokine (a) phenotype and renal outcome; (b) genotype and phenotype and (c) genotype and renal outcome. Since angiotensin-2 (AG2), modulates TGFß1 production, we determined whether angiotensin converting enzyme insertion/deletion (ACE I/D) genotype affects urinary TGFß1 phenotype as well as renal outcome.
Original languageEnglish
Pages (from-to)275-84
Number of pages10
Issue number1
Publication statusPublished - 2013


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