Cytokine phenotype, genotype, and renal outcomes at cardiac surgery

William T McBride; Penugonda S Prasad; Marilyn Armstrong; Christopher Patterson; Helen Gilliland; Andrew Drain; Alain Vuylsteke; Ray Latimer; Nadia Khalil; Alun Evans; François Cambien; Ian Young

doi:10.1016/j.cyto.2012.10.008

Cytokine phenotype, genotype, and renal outcomes at cardiac surgery

William T McBride, Penugonda S Prasad, Marilyn Armstrong, Christopher Patterson, Helen Gilliland, Andrew Drain, Alain Vuylsteke, Ray Latimer, Nadia Khalil, Alun Evans, François Cambien, Ian Young

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Cardiac surgery modulates pro- and anti-inflammatory cytokine balance involving plasma tumour necrosis factor alpha (TNFa) and interleukin-10 (IL-10) together with urinary transforming growth factor beta-1 (TGFß1), interleukin-1 receptor antagonist (IL1ra) and tumour necrosis factor soluble receptor-2 (TNFsr2). Effects on post-operative renal function are unclear. We investigated if following cardiac surgery there is a relationship between cytokine (a) phenotype and renal outcome; (b) genotype and phenotype and (c) genotype and renal outcome. Since angiotensin-2 (AG2), modulates TGFß1 production, we determined whether angiotensin converting enzyme insertion/deletion (ACE I/D) genotype affects urinary TGFß1 phenotype as well as renal outcome.

Original language	English
Pages (from-to)	275-84
Number of pages	10
Journal	Cytokine
Volume	61
Issue number	1
DOIs	https://doi.org/10.1016/j.cyto.2012.10.008
Publication status	Published - 2013

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10.1016/j.cyto.2012.10.008

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title = "Cytokine phenotype, genotype, and renal outcomes at cardiac surgery",

abstract = "Cardiac surgery modulates pro- and anti-inflammatory cytokine balance involving plasma tumour necrosis factor alpha (TNFa) and interleukin-10 (IL-10) together with urinary transforming growth factor beta-1 (TGF{\ss}1), interleukin-1 receptor antagonist (IL1ra) and tumour necrosis factor soluble receptor-2 (TNFsr2). Effects on post-operative renal function are unclear. We investigated if following cardiac surgery there is a relationship between cytokine (a) phenotype and renal outcome; (b) genotype and phenotype and (c) genotype and renal outcome. Since angiotensin-2 (AG2), modulates TGF{\ss}1 production, we determined whether angiotensin converting enzyme insertion/deletion (ACE I/D) genotype affects urinary TGF{\ss}1 phenotype as well as renal outcome.",

author = "McBride, {William T} and Prasad, {Penugonda S} and Marilyn Armstrong and Christopher Patterson and Helen Gilliland and Andrew Drain and Alain Vuylsteke and Ray Latimer and Nadia Khalil and Alun Evans and Fran{\c c}ois Cambien and Ian Young",

year = "2013",

doi = "10.1016/j.cyto.2012.10.008",

language = "English",

volume = "61",

pages = "275--84",

journal = "Cytokine",

issn = "1043-4666",

publisher = "Academic Press Inc.",

number = "1",

}

Cytokine phenotype, genotype, and renal outcomes at cardiac surgery. / McBride, William T; Prasad, Penugonda S; Armstrong, Marilyn; Patterson, Christopher; Gilliland, Helen; Drain, Andrew; Vuylsteke, Alain; Latimer, Ray; Khalil, Nadia; Evans, Alun; Cambien, François; Young, Ian.

In: Cytokine, Vol. 61, No. 1, 2013, p. 275-84.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Cytokine phenotype, genotype, and renal outcomes at cardiac surgery

AU - McBride, William T

AU - Prasad, Penugonda S

AU - Armstrong, Marilyn

AU - Patterson, Christopher

AU - Gilliland, Helen

AU - Drain, Andrew

AU - Vuylsteke, Alain

AU - Latimer, Ray

AU - Khalil, Nadia

AU - Evans, Alun

AU - Cambien, François

AU - Young, Ian

PY - 2013

Y1 - 2013

N2 - Cardiac surgery modulates pro- and anti-inflammatory cytokine balance involving plasma tumour necrosis factor alpha (TNFa) and interleukin-10 (IL-10) together with urinary transforming growth factor beta-1 (TGFß1), interleukin-1 receptor antagonist (IL1ra) and tumour necrosis factor soluble receptor-2 (TNFsr2). Effects on post-operative renal function are unclear. We investigated if following cardiac surgery there is a relationship between cytokine (a) phenotype and renal outcome; (b) genotype and phenotype and (c) genotype and renal outcome. Since angiotensin-2 (AG2), modulates TGFß1 production, we determined whether angiotensin converting enzyme insertion/deletion (ACE I/D) genotype affects urinary TGFß1 phenotype as well as renal outcome.

AB - Cardiac surgery modulates pro- and anti-inflammatory cytokine balance involving plasma tumour necrosis factor alpha (TNFa) and interleukin-10 (IL-10) together with urinary transforming growth factor beta-1 (TGFß1), interleukin-1 receptor antagonist (IL1ra) and tumour necrosis factor soluble receptor-2 (TNFsr2). Effects on post-operative renal function are unclear. We investigated if following cardiac surgery there is a relationship between cytokine (a) phenotype and renal outcome; (b) genotype and phenotype and (c) genotype and renal outcome. Since angiotensin-2 (AG2), modulates TGFß1 production, we determined whether angiotensin converting enzyme insertion/deletion (ACE I/D) genotype affects urinary TGFß1 phenotype as well as renal outcome.

U2 - 10.1016/j.cyto.2012.10.008

DO - 10.1016/j.cyto.2012.10.008

M3 - Article

C2 - 23137784

VL - 61

SP - 275

EP - 284

JO - Cytokine

JF - Cytokine

SN - 1043-4666

IS - 1

ER -

Cytokine phenotype, genotype, and renal outcomes at cardiac surgery

Abstract

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