Cytotoxicity of Mechanochemically Prepared Cu(II) Complexes

Aaron S. McCalmont; Gladys Amalia Ruiz Estrada; M. Cristina Lagunas; Wafa T. Al-Jamal; Deborah Crawford

doi:10.1021/acssuschemeng.0c04950

Cytotoxicity of Mechanochemically Prepared Cu(II) Complexes

Aaron S. McCalmont, Gladys Amalia Ruiz Estrada, M. Cristina Lagunas, Wafa T. Al-Jamal, Deborah Crawford^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Despite evidence that mechanochemistry has the potential to be a revolutionary manufacturing technique, the Pharma industry is still reluctant to introduce these new technologies into their manufacturing processes. Therefore, it is now time to pioneer the implementation of mechanochemistry in industry, by analysing the bioactive and physicochemical properties of mechanochemical products and comparing them with those obtained conventionally. Herein, we report for the first time, enhanced cytotoxicity towards ovarian cancer cell lines, as a result of preparing metallodrugs mechanochemically.

Original language	English
Journal	ACS Sustainable Chemistry & Engineering
DOIs	https://doi.org/10.1021/acssuschemeng.0c04950
Publication status	Published - 21 Sept 2020

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Cytotoxicity of Mechanochemically Prepared Cu(II) Complexes
Copyright © 2020 American Chemical Society. This work is made available online in accordance with the publisher’s policies. Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 734 KBLicence: Unspecified

Cristina Lagunas-Castedo
- C.Lagunasqub.acuk
- School of Chemistry and Chemical Engineering - Senior Lecturer
- Green and Sustainable Chemistry
Person: Academic

Cite this

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title = "Cytotoxicity of Mechanochemically Prepared Cu(II) Complexes",

abstract = "Despite evidence that mechanochemistry has the potential to be a revolutionary manufacturing technique, the Pharma industry is still reluctant to introduce these new technologies into their manufacturing processes. Therefore, it is now time to pioneer the implementation of mechanochemistry in industry, by analysing the bioactive and physicochemical properties of mechanochemical products and comparing them with those obtained conventionally. Herein, we report for the first time, enhanced cytotoxicity towards ovarian cancer cell lines, as a result of preparing metallodrugs mechanochemically.",

author = "McCalmont, {Aaron S.} and {Ruiz Estrada}, {Gladys Amalia} and Lagunas, {M. Cristina} and Al-Jamal, {Wafa T.} and Deborah Crawford",

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AU - McCalmont, Aaron S.

AU - Ruiz Estrada, Gladys Amalia

AU - Lagunas, M. Cristina

AU - Al-Jamal, Wafa T.

AU - Crawford, Deborah

PY - 2020/9/21

Y1 - 2020/9/21

N2 - Despite evidence that mechanochemistry has the potential to be a revolutionary manufacturing technique, the Pharma industry is still reluctant to introduce these new technologies into their manufacturing processes. Therefore, it is now time to pioneer the implementation of mechanochemistry in industry, by analysing the bioactive and physicochemical properties of mechanochemical products and comparing them with those obtained conventionally. Herein, we report for the first time, enhanced cytotoxicity towards ovarian cancer cell lines, as a result of preparing metallodrugs mechanochemically.

AB - Despite evidence that mechanochemistry has the potential to be a revolutionary manufacturing technique, the Pharma industry is still reluctant to introduce these new technologies into their manufacturing processes. Therefore, it is now time to pioneer the implementation of mechanochemistry in industry, by analysing the bioactive and physicochemical properties of mechanochemical products and comparing them with those obtained conventionally. Herein, we report for the first time, enhanced cytotoxicity towards ovarian cancer cell lines, as a result of preparing metallodrugs mechanochemically.

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DO - 10.1021/acssuschemeng.0c04950

M3 - Article

SN - 2168-0485

JO - ACS Sustainable Chemistry & Engineering

JF - ACS Sustainable Chemistry & Engineering

ER -

Cytotoxicity of Mechanochemically Prepared Cu(II) Complexes

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Cristina Lagunas-Castedo

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