Damage to plasmid DNA induced by low energy carbon ions

Christopher Hunniford, David Timson, R.J.H. Davies, Robert McCullough

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

The damage induced in supercoiled plasmid DNA molecules by 1-6 keV carbon ions has been investigated as a function of ion exposure, energy and charge state. The production of short linear fragments through multiple double strand breaks has been demonstrated and exponential exposure responses for each of the topoisomers have been found. The cross section for the loss of supercoiling was calculated to be (2.2 +/- 0.5) x 10(-14) cm(2) for 2 keVC(+) ions. For singly charged carbon ions, increased damage was observed with increasing ion energy. In the case of 2 keV doubly charged ions, the damage was greater than for singly charged ions of the same energy. These observations demonstrate that ion induced damage is a function of both the kinetic and potential energies of the ion.
Original languageEnglish
Article number005
Pages (from-to)3729-3740
Number of pages12
JournalPhysics in Medicine and Biology
Volume52
Issue number13
DOIs
Publication statusPublished - 07 Jul 2007

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physics and Astronomy (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Fingerprint

Dive into the research topics of 'Damage to plasmid DNA induced by low energy carbon ions'. Together they form a unique fingerprint.

Cite this