Deciphering tissue-induced Klebsiella pneumoniae lipid A structure

Enrique Llobet, Veronica Martinez-Moliner, David Moranta, Kathe M. Dahlstrom, Veronica Regueiro, Anna Tomas, Victoria Cano, Camino Pérez-Gutiérrez, Christian G Frank, Helena Fernández-Carrascoe, Jose Luis Insua, Tina A. Salminen, Junkal Garmendia, Jose A. Bengoechea

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

The host launches an antimicrobial defense program upon infection. A long-held belief is that pathogens prevent host recognition by remodeling their surface in response to different host microenvironments. Yet direct evidence that this happens in vivo is lacking. Here we report that the pathogen Klebsiella pneumoniae modifies one of its surface molecules, the lipopolysaccharide, in the lungs of mice to evade immune surveillance. These in vivo-induced changes are lost in bacteria grown after isolation from the tissues. These lipopolysaccharide modifications contribute to survival in vivo and mediate resistance to colistin, one of the last options to treat multidrug-resistant Klebsiella. This work opens the possibility of designing novel therapeutics targeting the enzymes responsible for the in vivo lipid A pattern.
Original languageEnglish
Pages (from-to)E6369-E6378
Number of pages10
JournalProceedings of the National Academy of Sciences of the United States of America
Volume112
Issue number46
Early online date02 Nov 2015
DOIs
Publication statusPublished - 2015

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