Deep sleep maintains learning efficiency of the human brain.

Sara Fattinger, Beukelaar TT de, Kathy L. Ruddy, Carina Volk, Natalie C. Heyse, Joshua A. Herbst, Richard H. R. Hahnloser, Nicole Wenderoth*, Reto Huber*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

91 Citations (Scopus)
29 Downloads (Pure)

Abstract

It is hypothesized that deep sleep is essential for restoring the brain’s capacity to learn efficiently, especially in regions heavily activated during the day. However, causal evidence in humans has been lacking due to the inability to sleep deprive one target area while keeping the natural sleep pattern intact. Here we introduce a novel approach to focally perturb deep sleep in motor cortex, and investigate the consequences on behavioural and neurophysiological markers of neuroplasticity arising from dedicated motor practice. We show that the capacity to undergo neuroplastic changes is reduced by wakefulness but restored during unperturbed sleep. This restorative process is markedly attenuated when slow waves are selectively perturbed in motor cortex, demonstrating that deep sleep is a requirement for maintaining sustainable learning efficiency.
Original languageEnglish
Article number15405
JournalNature Communications
Volume8
DOIs
Publication statusPublished - 22 May 2017
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience

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